DP00642: Thioredoxin glutathione reductaseFASTA viewXML view

General information
DisProt:DP00642
Name:Thioredoxin glutathione reductase
Synonym(s):Q962Y6_SCHMA
EC=1.6.4.5
First appeared in release:Release 5.2 (08/07/2010)
UniProt:Q962Y6
UniGene: 
SwissProt: Q962Y6_SCHMA
TrEMBL:  
NCBI (GI): 74822288
Source organism:Schistosoma mansoni (Blood fluke)
Sequence length:598
Percent disordered:0%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MPPADGTSQW LRKTVDSAAV ILFSKTTCPY CKKVKDVLAE AKIKHATIEL DQLSNGSAIQ - 60
KCLASFSKIE TVPQMFVRGK FIGDSQTVLK YYSNDELAGI VNESKYDYDL IVIGGGSGGL - 120
AAGKEAAKYG AKTAVLDYVE PTPIGTTWGL GGTCVNVGCI PKKLMHQAGL LSHALEDAEH - 180
FGWSLDRSKI SHNWSTMVEG VQSHIGSLNW GYKVALRDNQ VTYLNAKGRL ISPHEVQITD - 240
KNQKVSTITG NKIILATGER PKYPEIPGAV EYGITSDDLF SLPYFPGKTL VIGASYVALE - 300
CAGFLASLGG DVTVMVRSIL LRGFDQQMAE KVGDYMENHG VKFAKLCVPD EIKQLKVVDT - 360
ENNKPGLLLV KGHYTDGKKF EEEFETVIFA VGREPQLSKV LCETVGVKLD KNGRVVCTDD - 420
EQTTVSNVYA IGDINAGKPQ LTPVAIQAGR YLARRLFAGA TELTDYSNVA TTVFTPLEYG - 480
ACGLSEEDAI EKYGDKDIEV YHSNFKPLEW TVAHREDNVC YMKLVCRKSD NMRVLGLHVL - 540
GPNAGEITQG YAVAIKMGAT KADFDRTIGI HPTCSETFTT LHVTKKSGVS PIVSGCXG



Functional narrative    

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Region 1: 596-597

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:596 - 597
Length:2
Region sequence:

CX

Modification type: Native
PDB: 3H4K:A
Structural/functional type:  
Functional classes:  
Functional subclasses: Substrate/ligand binding
Detection methods:
  1. X-ray crystallography (100 K; pH: 7; BL14-1 Beamline at BESSY (MAR CCD detector); GSH 5 mM; HEPES 0.1 M; PEG 3350 20 %; potassium iodide 0.2 M; protein (sample) 5 mg/mL; resolution 2.55 A; wavelength 0.98 A)

References:
  1. Angelucci F, Sayed AA, Williams DL, Boumis G, Brunori M, Dimastrogiovanni D, Miele AE, Pauly F, Bellelli A. "Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects." J Biol Chem. 2009; 284(42): 28977-85. PubMed: 19710012

Comments:
Amino acid 597 "X" is selenocysteine (Sec).




References

  1. Angelucci F, Sayed AA, Williams DL, Boumis G, Brunori M, Dimastrogiovanni D, Miele AE, Pauly F, Bellelli A. "Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects." J Biol Chem. 2009; 284(42): 28977-85. PubMed: 19710012



Comments


AV (8-2-2010) PubMed: 19710012


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