| General information | | DisProt: | DP00642 | | Name: | Thioredoxin glutathione reductase | | Synonym(s): | Q962Y6_SCHMA
EC=1.6.4.5
| | First appeared in release: | Release 5.2 (08/07/2010) | | UniProt: | Q962Y6 | | UniGene: | | | SwissProt: | Q962Y6_SCHMA | | TrEMBL: | | | NCBI (GI): | 74822288 | | Source organism: | Schistosoma mansoni (Blood fluke) | | Sequence length: | 598 | | Percent disordered: | 0% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
| | | | | |
MPPADGTSQW LRKTVDSAAV ILFSKTTCPY CKKVKDVLAE AKIKHATIEL DQLSNGSAIQ - 60
KCLASFSKIE TVPQMFVRGK FIGDSQTVLK YYSNDELAGI VNESKYDYDL IVIGGGSGGL - 120
AAGKEAAKYG AKTAVLDYVE PTPIGTTWGL GGTCVNVGCI PKKLMHQAGL LSHALEDAEH - 180
FGWSLDRSKI SHNWSTMVEG VQSHIGSLNW GYKVALRDNQ VTYLNAKGRL ISPHEVQITD - 240
KNQKVSTITG NKIILATGER PKYPEIPGAV EYGITSDDLF SLPYFPGKTL VIGASYVALE - 300
CAGFLASLGG DVTVMVRSIL LRGFDQQMAE KVGDYMENHG VKFAKLCVPD EIKQLKVVDT - 360
ENNKPGLLLV KGHYTDGKKF EEEFETVIFA VGREPQLSKV LCETVGVKLD KNGRVVCTDD - 420
EQTTVSNVYA IGDINAGKPQ LTPVAIQAGR YLARRLFAGA TELTDYSNVA TTVFTPLEYG - 480
ACGLSEEDAI EKYGDKDIEV YHSNFKPLEW TVAHREDNVC YMKLVCRKSD NMRVLGLHVL - 540
GPNAGEITQG YAVAIKMGAT KADFDRTIGI HPTCSETFTT LHVTKKSGVS PIVSGCXG
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| Functional narrative |
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 596 - 597 | | Length: | 2 | | Region sequence: |
CX | | Modification type: | Native
| | PDB: | 3H4K:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | Substrate/ligand binding
| Detection methods:
- X-ray crystallography (100 K; pH: 7; BL14-1 Beamline at BESSY (MAR CCD detector); GSH 5 mM; HEPES 0.1 M; PEG 3350 20 %; potassium iodide 0.2 M; protein (sample) 5 mg/mL; resolution 2.55 A; wavelength 0.98 A)
| References:
- Angelucci F, Sayed AA, Williams DL, Boumis G, Brunori M, Dimastrogiovanni D, Miele AE, Pauly F, Bellelli A. "Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects." J Biol Chem. 2009; 284(42): 28977-85. PubMed: 19710012
| Comments:Amino acid 597 "X" is selenocysteine (Sec).
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| References |
- Angelucci F, Sayed AA, Williams DL, Boumis G, Brunori M, Dimastrogiovanni D, Miele AE, Pauly F, Bellelli A. "Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects." J Biol Chem. 2009; 284(42): 28977-85. PubMed: 19710012
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| Comments |
AV (8-2-2010) PubMed: 19710012
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| If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
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