| General information | | DisProt: | DP00654 | | Name: | Fatty acid multifunctional protein | | Synonym(s): | MFP2_ARATH
MFP2
AtMFP2
| | First appeared in release: | Release 5.3 (09/21/2010) | | UniProt: | Q9ZPI5 | | UniGene: | | | SwissProt: | MFP2_ARATH | | TrEMBL: | | | NCBI (GI): | | | Source organism: | Arabidopsis thaliana (Mouse-ear cress) | | Sequence length: | 725 | | Percent disordered: | 5% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
| | | | | |
MDSRTKGKTV MEVGGDGVAV ITLINPPVNS LSFDVLYNLK SNYEEALSRN DVKAIVITGA - 60
KGRFSGGFDI SGFGEMQKGN VKEPKAGYIS IDIITDLLEA ARKPSVAAID GLALGGGLEL - 120
AMACHARISA PAAQLGLPEL QLGVIPGFGG TQRLPRLVGL TKALEMILTS KPVKAEEGHS - 180
LGLIDAVVPP AELVTTARRW ALDIVGRRKP WVSSVSKTDK LPPLGEAREI LTFAKAQTLK - 240
RAPNMKHPLM CLDAIEVGIV SGPRAGLEKE AEVASQVVKL DTTKGLIHVF FSQRGTAKVP - 300
GVTDRGLVPR KIKKVAIIGG GLMGSGIATA LILSNYPVIL KEVNEKFLEA GIGRVKANLQ - 360
SRVRKGSMSQ EKFEKTMSLL KGSLDYESFR DVDMVIEAVI ENISLKQQIF ADLEKYCPQH - 420
CILASNTSTI DLNKIGERTK SQDRIVGAHF FSPAHIMPLL EIVRTNHTSA QVIVDLLDVG - 480
KKIKKTPVVV GNCTGFAVNR MFFPYTQAAM FLVECGADPY LIDRAISKFG MPMGPFRLCD - 540
LVGFGVAIAT ATQFIENFSE RTYKSMIIPL MQEDKRAGEA TRKGFYLYDD KRKAKPDPEL - 600
KKYIEKARSI SGVKLDPKLA NLSEKDIIEM TFFPVVNEAC RVFAEGIAVK AADLDIAGIM - 660
GMGFPPYRGG IMFWADSIGS KYIYSRLDEW SKAYGEFFKP CAFLAERGSK GVLLSAPVKQ - 720
ASSRL
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| Functional narrative |
Belongs to the enoyl-CoA hydratase/isomerase family. Functions in fatty acid degradation via peroxisomal beta-oxidation.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
|
| Region 1 | | Type: | Disordered | | Name: | flexible loop of ECH domain | | Location: | 71 - 82 | | Length: | 12 | | Region sequence: |
SGFGEMQKGNVK | | Modification type: | Native
| | PDB: | 2WTB:A | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | Modification site
| | Functional subclasses: | Acetylation
| Detection methods:
- X-ray crystallography
| References:
- Arent S, Christensen CE, Pye VE, Nørgaard A, Henriksen A. "The multifunctional protein in peroxisomal beta-oxidation: structure and substrate specificity of the arabidopsis thaliana protein MFP2." J. Biol. Chem.. 2010; 285(31): 24066-77. PubMed: 20463021
| Comments:
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| Region 2 | | Type: | Disordered | | Name: | flexible loop of the HACD-N domain | | Location: | 365 - 368 | | Length: | 4 | | Region sequence: |
KGSM | | Modification type: | Native
| | PDB: | 2WTB:A | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | Modification site
| | Functional subclasses: | Intraprotein interaction
| Detection methods:
- X-ray crystallography
| References:
- Arent S, Christensen CE, Pye VE, Nørgaard A, Henriksen A. "The multifunctional protein in peroxisomal beta-oxidation: structure and substrate specificity of the arabidopsis thaliana protein MFP2." J. Biol. Chem.. 2010; 285(31): 24066-77. PubMed: 20463021
| Comments:
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| Region 3 | | Type: | Disordered | | Name: | flexible loop of the HACD-C domain | | Location: | 576 - 596 | | Length: | 21 | | Region sequence: |
RAGEATRKGFYLYDDKRKAKP | | Modification type: | Native
| | PDB: | 2WTB:A | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | Modification site
| | Functional subclasses: | Intraprotein interaction
| Detection methods:
- X-ray crystallography
| References:
- Arent S, Christensen CE, Pye VE, Nørgaard A, Henriksen A. "The multifunctional protein in peroxisomal beta-oxidation: structure and substrate specificity of the arabidopsis thaliana protein MFP2." J. Biol. Chem.. 2010; 285(31): 24066-77. PubMed: 20463021
| Comments:
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| References |
- Arent S, Christensen CE, Pye VE, Nørgaard A, Henriksen A. "The multifunctional protein in peroxisomal beta-oxidation: structure and substrate specificity of the arabidopsis thaliana protein MFP2." J. Biol. Chem.. 2010; 285(31): 24066-77. PubMed: 20463021
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| Comments |
Sent for AV - PubMed: 20463021 (8-26-2010)
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