DP00654: Fatty acid multifunctional proteinFASTA viewXML view

General information
DisProt:DP00654
Name:Fatty acid multifunctional protein
Synonym(s):MFP2_ARATH
MFP2
AtMFP2
First appeared in release:Release 5.3 (09/21/2010)
UniProt:Q9ZPI5
UniGene: 
SwissProt: MFP2_ARATH
TrEMBL:  
NCBI (GI):  
Source organism:Arabidopsis thaliana (Mouse-ear cress)
Sequence length:725
Percent disordered:5%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MDSRTKGKTV MEVGGDGVAV ITLINPPVNS LSFDVLYNLK SNYEEALSRN DVKAIVITGA - 60
KGRFSGGFDI SGFGEMQKGN VKEPKAGYIS IDIITDLLEA ARKPSVAAID GLALGGGLEL - 120
AMACHARISA PAAQLGLPEL QLGVIPGFGG TQRLPRLVGL TKALEMILTS KPVKAEEGHS - 180
LGLIDAVVPP AELVTTARRW ALDIVGRRKP WVSSVSKTDK LPPLGEAREI LTFAKAQTLK - 240
RAPNMKHPLM CLDAIEVGIV SGPRAGLEKE AEVASQVVKL DTTKGLIHVF FSQRGTAKVP - 300
GVTDRGLVPR KIKKVAIIGG GLMGSGIATA LILSNYPVIL KEVNEKFLEA GIGRVKANLQ - 360
SRVRKGSMSQ EKFEKTMSLL KGSLDYESFR DVDMVIEAVI ENISLKQQIF ADLEKYCPQH - 420
CILASNTSTI DLNKIGERTK SQDRIVGAHF FSPAHIMPLL EIVRTNHTSA QVIVDLLDVG - 480
KKIKKTPVVV GNCTGFAVNR MFFPYTQAAM FLVECGADPY LIDRAISKFG MPMGPFRLCD - 540
LVGFGVAIAT ATQFIENFSE RTYKSMIIPL MQEDKRAGEA TRKGFYLYDD KRKAKPDPEL - 600
KKYIEKARSI SGVKLDPKLA NLSEKDIIEM TFFPVVNEAC RVFAEGIAVK AADLDIAGIM - 660
GMGFPPYRGG IMFWADSIGS KYIYSRLDEW SKAYGEFFKP CAFLAERGSK GVLLSAPVKQ - 720
ASSRL



Functional narrative    

Belongs to the enoyl-CoA hydratase/isomerase family. Functions in fatty acid degradation via peroxisomal beta-oxidation.

Region 1: 71-82 Region 2: 365-368 Region 3: 576-596

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:flexible loop of ECH domain
Location:71 - 82
Length:12
Region sequence:

SGFGEMQKGNVK

Modification type: Native
PDB: 2WTB:A
Structural/functional type: Relationship to function unknown
Functional classes: Modification site
Functional subclasses: Acetylation
Detection methods:
  1. X-ray crystallography

References:
  1. Arent S, Christensen CE, Pye VE, Nørgaard A, Henriksen A. "The multifunctional protein in peroxisomal beta-oxidation: structure and substrate specificity of the arabidopsis thaliana protein MFP2." J. Biol. Chem.. 2010; 285(31): 24066-77. PubMed: 20463021

Comments:
 



Region 2
Type:Disordered
Name:flexible loop of the HACD-N domain
Location:365 - 368
Length:4
Region sequence:

KGSM

Modification type: Native
PDB: 2WTB:A
Structural/functional type: Relationship to function unknown
Functional classes: Modification site
Functional subclasses: Intraprotein interaction
Detection methods:
  1. X-ray crystallography

References:
  1. Arent S, Christensen CE, Pye VE, Nørgaard A, Henriksen A. "The multifunctional protein in peroxisomal beta-oxidation: structure and substrate specificity of the arabidopsis thaliana protein MFP2." J. Biol. Chem.. 2010; 285(31): 24066-77. PubMed: 20463021

Comments:
 



Region 3
Type:Disordered
Name:flexible loop of the HACD-C domain
Location:576 - 596
Length:21
Region sequence:

RAGEATRKGFYLYDDKRKAKP

Modification type: Native
PDB: 2WTB:A
Structural/functional type: Relationship to function unknown
Functional classes: Modification site
Functional subclasses: Intraprotein interaction
Detection methods:
  1. X-ray crystallography

References:
  1. Arent S, Christensen CE, Pye VE, Nørgaard A, Henriksen A. "The multifunctional protein in peroxisomal beta-oxidation: structure and substrate specificity of the arabidopsis thaliana protein MFP2." J. Biol. Chem.. 2010; 285(31): 24066-77. PubMed: 20463021

Comments:
 



References

  1. Arent S, Christensen CE, Pye VE, Nørgaard A, Henriksen A. "The multifunctional protein in peroxisomal beta-oxidation: structure and substrate specificity of the arabidopsis thaliana protein MFP2." J. Biol. Chem.. 2010; 285(31): 24066-77. PubMed: 20463021



Comments


Sent for AV - PubMed: 20463021 (8-26-2010)


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