| General information | | DisProt: | DP00662 | | Name: | Inner membrane protein ALBINO3, chloroplastic [Isoform 1] | | Synonym(s): | ALB3_ARATH
Alb3
Alb3 insertase
| | First appeared in release: | Release 5.1 (05/28/2010) | | UniProt: | Q8LBP4-1 | | UniGene: | At.10324 | | SwissProt: | ALB3_ARATH | | TrEMBL: | | | NCBI (GI): | 38372238 | | Source organism: | Arabidopsis thaliana (Mouse-ear cress) | | Sequence length: | 462 | | Percent disordered: | 27% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MARVLVSSPS SFFGSPLIKP SSSLRHSGVG GGGTAQFLPY RSNNNKLFTT STTVRFSLNE - 60
IPPFHGLDSS VDIGAIFTRA ESLLYTIADA AVVGADSVVT TDSSAVQKSG GWFGFISDAM - 120
ELVLKILKDG LSAVHVPYAY GFAIILLTII VKAATYPLTK QQVESTLAMQ NLQPKIKAIQ - 180
QRYAGNQERI QLETSRLYKQ AGVNPLAGCL PTLATIPVWI GLYQALSNVA NEGLFTEGFF - 240
WIPSLGGPTS IAARQSGSGI SWLFPFVDGH PPLGWYDTVA YLVLPVLLIA SQYVSMEIMK - 300
PPQTDDPAQK NTLLVFKFLP LMIGYFALSV PSGLSIYWLT NNVLSTAQQV YLRKLGGAKP - 360
NMDENASKII SAGRAKRSIA QPDDAGERFR QLKEQEKRSK KNKAVAKDTV ELVEESQSES - 420
EEGSDDEEEE AREGALASST TSKPLPEVGQ RRSKRSKRKR TV
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| Functional narrative |
Required for the insertion of some light harvesting chlorophyll-binding proteins (LHCP) into the chloroplast thylakoid membrane. Required for the insertion of LHCB1, LHCB4.1 and LHCB5 proteins into thylakoid membrane, while it is not required for insertion of proteins psbX, psbW and psbY.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered - Extended | | Name: | A3CT (C-terminal domain) | | Location: | 339 - 462 | | Length: | 124 | | Region sequence: |
LTNNVLSTAQQVYLRKLGGAKPNMDENASKIISAGRAKRSIAQPDDAGERFRQLKEQEKR
SKKNKAVAKDTVELVEESQSESEEGSDDEEEEAREGALASSTTSKPLPEVGQRRSKRSKR
KRTV | | Modification type: | Fragment
Monomeric
Native
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Molecular recognition effectors
| | Functional subclasses: | Protein-protein binding
| Detection methods:
- Circular dichroism (CD) spectroscopy, far-UV (288 K; pH: 7.5; A3CT 6 uM; potassium posphate 10 mM)
- Size exclusion/gel filtration chromatography (pH: 7.5; DTT 1 mM; EDTA 1 mM; Hepes/NaOH 20 mM; MgCl(2) 2 mM; NaCl 150 mM)
| References:
- Falk S, Ravaud S, Koch J, Sinning I. "The C Terminus of the Alb3 Membrane Insertase Recruits cpSRP43 to the Thylakoid Membrane." J Biol Chem. 2010; 285(8): 5954-62. PubMed: 20018841
| Comments:According to Falk et al., Alb3 recruits the transit complex of cpSRP43-cpSRP54-LHCP to the thylakoid membrane as a prerequisite of efficient insertion of LHPC into the membrane.
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| Comments |
Additional UniGene ID: Rra.7942
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