DP00695: BirA bifunctional proteinFASTA viewXML view

General information
DisProt:DP00695
Name:BirA bifunctional protein
Synonym(s):P96884_MYCTU
First appeared in release:Release 5.2 (08/07/2010)
UniProt:P96884
UniGene: 
SwissProt: P96884_MYCTU
TrEMBL:  
NCBI (GI):  
Source organism:Mycobacterium tuberculosis
Sequence length:266
Percent disordered:14%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MTDRDRLRPP LDERSLRDQL IGAGSGWRQL DVVAQTGSTN ADLLARAASG ADIDGVVLIA - 60
EHQTAGRGRH GRGWAATARA QIILSVGVRV VDVPVQAWGW LSLAAGLAVL DSVAPLIAVP - 120
PAETGLKWPN DVLARGGKLA GILAEVAQPF VVLGVGLNVT QAPEEVDPDA TSLLDLGVAA - 180
PDRNRIASRL LRELEARIIQ WRNANPQLAA DYRARSLTIG SRVRVELPGG QDVVGIARDI - 240
DDQGRLCLDV GGRTVVVSAG DVVHLR

Region 1: 60-81 Region 2: 159-172

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:L4
Location:60 - 81
Length:22
Region sequence:

AEHQTAGRGRHGRGWAATARAQ

Modification type: Native
PDB: 3L2Z:A, 3L2Z:B
Structural/functional type: Function arises via a disorder to order transition
Functional classes:  
Functional subclasses: Flexible linkers/spacers
Substrate/ligand binding
Detection methods:
  1. X-ray crystallography (293 K; pH: 7.5; HEPES 0.1 M; PEG 4000 or PEG 8000 (w/v) 12 %; protein (sample) 5 mg/mL; resolution 2.8 A)
References:
  1. Gupta,Vibha, Rakesh K. Gupta, Garima Khare, Dinakar M. Salunke, Avadhesha Surolia, and Anil K. Tyagi. "Structural Ordering of Disordered Ligand-Binding Loops of Biotin Protein Ligase into Active Conformations as a Consequence of Dehydration." PLoS One. 2010; 5(2). PubMed: 20169168
Comments:
 



Region 2
Type:Disordered
Name:L8
Location:159 - 172
Length:14
Region sequence:

VTQAPEEVDPDATS

Modification type: Native
PDB: 3L2Z:A, 3L2Z:B
Structural/functional type: Function arises via a disorder to order transition
Functional classes:  
Functional subclasses: Flexible linkers/spacers
Substrate/ligand binding
Detection methods:
  1. X-ray crystallography (293 K; pH: 7.5; HEPES 0.1 M; PEG 4000 or PEG 8000 12 %; protein (sample) 5 mg/mL; resolution 2.8 A)
References:
  1. Gupta,Vibha, Rakesh K. Gupta, Garima Khare, Dinakar M. Salunke, Avadhesha Surolia, and Anil K. Tyagi. "Structural Ordering of Disordered Ligand-Binding Loops of Biotin Protein Ligase into Active Conformations as a Consequence of Dehydration." PLoS One. 2010; 5(2). PubMed: 20169168
Comments:
 



References

  1. Gupta,Vibha, Rakesh K. Gupta, Garima Khare, Dinakar M. Salunke, Avadhesha Surolia, and Anil K. Tyagi. "Structural Ordering of Disordered Ligand-Binding Loops of Biotin Protein Ligase into Active Conformations as a Consequence of Dehydration." PLoS One. 2010; 5(2). PubMed: 20169168



Comments


AV (8-3-2010) PubMed: 20169168


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