DP00732: Botulinum neurotoxin type EFASTA viewXML view

General information
DisProt:DP00732
Name:Botulinum neurotoxin type E
Synonym(s):BXE_CLOBO
Bontoxilysin-E
BoNT/E
Botulinum neurotoxin E light chain [cleavage product 1] (aa 2-422)
Botulinum neurotoxin E heavy chain [cleavage product 2] (aa 423-1251)
First appeared in release:Release 6.01 (10/15/2012)
UniProt:Q00496
UniGene: 
SwissProt: BXE_CLOBO
TrEMBL:  
NCBI (GI):  
Source organism:Clostridium botulinum
Sequence length:1251
Percent disordered:-1%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MPKINSFNYN DPVNDRTILY IKPGGCQEFY KSFNIMKNIW IIPERNVIGT TPQDFHPPTS - 60
LKNGDSSYYD PNYLQSDEEK DRFLKIVTKI FNRINNNLSG GILLEELSKA NPYLGNDNTP - 120
DNQFHIGDAS AVEIKFSNGS QDILLPNVII MGAEPDLFET NSSNISLRNN YMPSNHRFGS - 180
IAIVTFSPEY SFRFNDNCMN EFIQDPALTL MHELIHSLHG LYGAKGITTK YTITQKQNPL - 240
ITNIRGTNIE EFLTFGGTDL NIITSAQSND IYTNLLADYK KIASKLSKVQ VSNPLLNPYK - 300
DVFEAKYGLD KDASGIYSVN INKFNDIFKK LYSFTEFDLR TKFQVKCRQT YIGQYKYFKL - 360
SNLLNDSIYN ISEGYNINNL KVNFRGQNAN LNPRIITPIT GRGLVKKIIR FCKNIVSVKG - 420
IRKSICIEIN NGELFFVASE NSYNDDNINT PKEIDDTVTS NNNYENDLDQ VILNFNSESA - 480
PGLSDEKLNL TIQNDAYIPK YDSNGTSDIE QHDVNELNVF FYLDAQKVPE GENNVNLTSS - 540
IDTALLEQPK IYTFFSSEFI NNVNKPVQAA LFVSWIQQVL VDFTTEANQK STVDKIADIS - 600
IVVPYIGLAL NIGNEAQKGN FKDALELLGA GILLEFEPEL LIPTILVFTI KSFLGSSDNK - 660
NKVIKAINNA LKERDEKWKE VYSFIVSNWM TKINTQFNKR KEQMYQALQN QVNAIKTIIE - 720
SKYNSYTLEE KNELTNKYDI KQIENELNQK VSIAMNNIDR FLTESSISYL MKIINEVKIN - 780
KLREYDENVK TYLLNYIIQH GSILGESQQE LNSMVTDTLN NSIPFKLSSY TDDKILISYF - 840
NKFFKRIKSS SVLNMRYKND KYVDTSGYDS NININGDVYK YPTNKNQFGI YNDKLSEVNI - 900
SQNDYIIYDN KYKNFSISFW VRIPNYDNKI VNVNNEYTII NCMRDNNSGW KVSLNHNEII - 960
WTFEDNRGIN QKLAFNYGNA NGISDYINKW IFVTITNDRL GDSKLYINGN LIDQKSILNL - 1020
GNIHVSDNIL FKIVNCSYTR YIGIRYFNIF DKELDETEIQ TLYSNEPNTN ILKDFWGNYL - 1080
LYDKEYYLLN VLKPNNFIDR RKDSTLSINN IRSTILLANR LYSGIKVKIQ RVNNSSTNDN - 1140
LVRKNDQVYI NFVASKTHLF PLYADTATTN KEKTIKISSS GNRFNQVVVM NSVGNCTMNF - 1200
KNNNGNNIGL LGFKADTVVA STWYYTHMRD HTNSNGCFWN FISEEHGWQE K



Functional narrative    

Function: Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the 180-Arg-|-Ile- 181 bond in SNAP-25.
CATALYTIC ACTIVITY: Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
COFACTOR: Binds 1 zinc ion per subunit (By similarity).
SUBUNIT: Disulfide-linked heterodimer of a light chain (L) and a heavy chain (H). The light chain has the pharmacological activity, while the N- and C-terminal of the heavy chain mediate channel formation and toxin binding, respectively.


Subcellular Location: Botulinum neurotoxin E light chain: Secreted. Host cytoplasm, host cytosol.


Subcellular Location: Botulinum neurotoxin E heavy chain: Secreted. Host cell junction, host synapse, host presynaptic cell membrane (Potential).
MISCELLANEOUS: There are seven antigenically distinct forms of botulinum neurotoxin: Types A, B, C1, D, E, F, and G.
SIMILARITY: Belongs to the peptidase M27 family.
WEB RESOURCE: Name=BotDB - A Database Resource for Clostridial Neurotoxins; URL='http://botdb.abcc.ncifcrf.gov/';
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Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Comments


Characterization of disorder is found on Botulinum neurotoxin type E light chain (DP000732_C001) which is cleavage product 1 of full-length Botulinum neurotoxin type E.


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