| General information | | DisProt: | DP00747 | | Name: | Natriuretic peptides A | | Synonym(s): | ANF_HUMAN
CDD-ANF
Prepronatriodilatin
Cardiodilatin-related peptide [cleavage product 1] (aa 26-55)
CDP
Atrial natriuretic factor [cleavage product 2] (aa 124-151)
ANF
Atrial natriuretic peptide
ANP
| | First appeared in release: | Release 6.02 (05/24/2013) | | UniProt: | P01160 | | UniGene: | Hs.75640 | | SwissProt: | ANF_HUMAN | | TrEMBL: | | | NCBI (GI): | | | Source organism: | Homo sapiens (Human) | | Sequence length: | 153 | | Percent disordered: | -1% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
| | | | | |
MSSFSTTTVS FLLLLAFQLL GQTRANPMYN AVSNADLMDF KNLLDHLEEK MPLEDEVVPP - 60
QVLSEPNEEA GAALSPLPEV PPWTGEVSPA QRDGGALGRG PWDSSDRSAL LKSKLRALLT - 120
APRSLRRSSC FGGRMDRIGA QSGLGCNSFR YRR
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| Functional narrative |
Characterization of disorder is found on Atrial natriuretic factor
(DP00747_C002)
which is cleavage product 2 of full-length Natriuretic peptides A.
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Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Belongs to the natriuretic peptide family.
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| Map of ordered and disordered regions |
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