DP00002: 60S acidic ribosomal protein P2-betaFASTA viewXML view

General information
DisProt:DP00002
Name:60S acidic ribosomal protein P2-beta
Synonym(s):RLA4_YEAST
L45
L12EIA
YPA1
YL44C
YP2beta
P2B
First appeared in release:Release 1.0 (08/01/2003)
UniProt:P02400
UniGene: 
SwissProt: RLA4_YEAST
TrEMBL:  
NCBI (GI): 133071
Source organism:Saccharomyces cerevisiae (Baker's yeast)
Sequence length:110
Percent disordered:100%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MKYLAAYLLL VQGGNAAPSA ADIKAVVESV GAEVDEARIN ELLSSLEGKG SLEEIIAEGQ - 60
KKFATVPTGG ASSAAAGAAG AAAGGDAAEE EKEEEAKEES DDDMGFGLFD



Functional narrative    

Plays an important role in the elongation step of protein synthesis. Belongs to the ribosomal protein L12P family.

Region 1: 1-110

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered - Molten Globule
Name: 
Location:1 - 110
Length:110
Region sequence:

MKYLAAYLLLVQGGNAAPSAADIKAVVESVGAEVDEARINELLSSLEGKGSLEEIIAEGQ
KKFATVPTGGASSAAAGAAGAAAGGDAAEEEKEEEAKEESDDDMGFGLFD

Modification type: Native
PDB:  
Structural/functional type: Function arises via a molten globule to order transition
Functional classes: Molecular recognition effectors
Functional subclasses: Protein-protein binding
Detection methods:
  1. Circular dichroism (CD) spectroscopy, far-UV

  2. Nuclear magnetic resonance (NMR)

  3. Analytical ultracentrifugation

  4. Hydrogen-deuterium exchange

  5. Stability at thermal extremes

References:
  1. Zurdo J, Gonzalez C, Sanz JM, Rico M, Remacha M, Ballesta JP. "Structural differences between Saccharomyces cerevisiae ribosomal stalk proteins P1 and P2 support their functional diversity." Biochemistry. 2000; 39(30): 8935-43. PubMed: 10913306

  2. Zurdo J, Sanz JM, Gonzalez C, Rico M, Ballesta JP. "The exchangeable yeast ribosomal acidic protein YP2beta shows characteristics of a partly folded state under physiological conditions." Biochemistry. 1997; 36(31): 9625-35. PubMed: 9236009

Comments:
 



References

  1. Remacha M, Saenz-Robles MT, Vilella MD, Ballesta JP. "Independent genes coding for three acidic proteins of the large ribosomal subunit from Saccharomyces cerevisiae." J Biol Chem. 1988; 263(19): 9094-9101. PubMed: 2837476


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