General information | DisProt: | DP00002 | Name: | 60S acidic ribosomal protein P2-beta | Synonym(s): | RLA4_YEAST
L45
L12EIA
YPA1
YL44C
YP2beta
P2B
| First appeared in release: | Release 1.0 (08/01/2003) | UniProt: | P02400 | UniGene: | | SwissProt: | RLA4_YEAST | TrEMBL: | | NCBI (GI): | 133071 | Source organism: | Saccharomyces cerevisiae (Baker's yeast) | Sequence length: | 110 | Percent disordered: | 100% | Homologues: | |
Native sequence |
10 20 30 40 50 60 | | | | | | MKYLAAYLLL VQGGNAAPSA ADIKAVVESV GAEVDEARIN ELLSSLEGKG SLEEIIAEGQ - 60 KKFATVPTGG ASSAAAGAAG AAAGGDAAEE EKEEEAKEES DDDMGFGLFD
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Functional narrative |
Plays an important role in the elongation step of protein synthesis. Belongs to the ribosomal protein L12P family.
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Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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Region 1 | Type: | Disordered - Molten Globule | Name: | | Location: | 1 - 110 | Length: | 110 | Region sequence: |
MKYLAAYLLLVQGGNAAPSAADIKAVVESVGAEVDEARINELLSSLEGKGSLEEIIAEGQ KKFATVPTGGASSAAAGAAGAAAGGDAAEEEKEEEAKEESDDDMGFGLFD | Modification type: | Native
| PDB: | | Structural/functional type: | Function arises via a molten globule to order transition | Functional classes: | Molecular recognition effectors
| Functional subclasses: | Protein-protein binding
| Detection methods:
- Circular dichroism (CD) spectroscopy, far-UV
- Nuclear magnetic resonance (NMR)
- Analytical ultracentrifugation
- Hydrogen-deuterium exchange
- Stability at thermal extremes
| References:
- Zurdo J, Gonzalez C, Sanz JM, Rico M, Remacha M, Ballesta JP. "Structural differences between Saccharomyces cerevisiae ribosomal stalk proteins P1 and P2 support their functional diversity." Biochemistry. 2000; 39(30): 8935-43. PubMed: 10913306
- Zurdo J, Sanz JM, Gonzalez C, Rico M, Ballesta JP. "The exchangeable yeast ribosomal acidic protein YP2beta shows characteristics of a partly folded state under physiological conditions." Biochemistry. 1997; 36(31): 9625-35. PubMed: 9236009
| Comments:
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References |
- Remacha M, Saenz-Robles MT, Vilella MD, Ballesta JP. "Independent genes coding for three acidic proteins of the large ribosomal subunit from Saccharomyces cerevisiae." J Biol Chem. 1988; 263(19): 9094-9101. PubMed: 2837476
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