| General information | | DisProt: | DP00009 | | Name: | Transcription initiation factor IIA small subunit | | Synonym(s): | TOA2_YEAST
TFIIA 13.5 kDa subunit
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | P32774 | | UniGene: | | | SwissProt: | TOA2_YEAST | | TrEMBL: | | | NCBI (GI): | 418109 | | Source organism: | Saccharomyces cerevisiae (Baker's yeast) | | Sequence length: | 122 | | Percent disordered: | 11% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MAVPGYYELY RRSTIGNSLV DALDTLISDG RIEASLAMRV LETFDKVVAE TLKDNTQSKL - 60
TVKGNLDTYG FCDDVWTFIV KNCQVTVEDS HRDASQNGSG DSQSVISVDK LRIVACNSKK - 120
SE
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| Functional narrative |
TFIIA is a component of the transcription machinery of RNA polymerase II and implicated in the regulation of basal transcription. Interacts with TBP (the TATA-binding protein).
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 90 - 102 | | Length: | 13 | | Region sequence: |
DSHRDASQNGSGDSQ | | Modification type: | Complex
| | PDB: | | | Structural/functional type: | | | Functional classes: | Molecular assembly
| | Functional subclasses: | Transactivation (transcriptional activation)
Protein-protein binding
| Detection methods:
- X-ray crystallography (103 K; )
| References:
- Tan S, Hunziker Y, Sargent DF, Richmond TJ. "Crystal structure of a yeast TFIIA/TBP/DNA complex." Nature. 1996; 381(6578): 127-51. PubMed: 8610010
| Comments:
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| References |
- Bleichenbacher M, Tan S, Richmond TJ. "Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes." J Mol Biol. 2003; 332(4): 783-93. PubMed: 12972251
- Burley SK. "Picking up the TAB." Nature. 1996; 381(6578): 112-3. PubMed: 8610004
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