| General information | | DisProt: | DP00013 | | Name: | Choriogonadotropin subunit beta | | Synonym(s): | CGHB_HUMAN
CG-beta
Chorionic gonadotrophin chain beta
HCG
Human chorionic gonadotropin
| | First appeared in release: | Release 1.0 (08/01/2003) | | UniProt: | P01233 | | UniGene: | Hs.172944 | | SwissProt: | CGHB_HUMAN | | TrEMBL: | | | NCBI (GI): | 116184 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 145 | | Percent disordered: | 23% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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SKEPLRPRCR PINATLAVEK EGCPVCITVN TTICAGYCPT MTRVLQGVLP ALPQVVCNYR - 60
DVRFESIRLP GCPRGVNPVV SYAVALSCQC ALCRRSTTDC GGPKDHPLTC DDPRFQDSSS - 120
SKAPPPSLPS PSRLPGPSDT PILPQ
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| Functional narrative |
Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | C-terminal | | Location: | 112 - 145 | | Length: | 34 | | Region sequence: |
DPRFQDSSSSKAPPPSLPSPSRLPGPSDTPILPQ | | Modification type: | Monomeric
Native
| | PDB: | 1HRP:B | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | Intraprotein interaction
Glycosylation
| Detection methods:
- X-ray crystallography (298 K; resolution 3 A; Siemens/Xentronics P1000 (area detector and synchrotron (film)); wavelength (1.54 and 1.48 A))
| References:
- Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW. "Crystal structure of human chorionic gonadotropin." Nature. 1994; 369(6480): 455-61. PubMed: 8202136
| Comments:
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| References |
- Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW. "Crystal structure of human chorionic gonadotropin." Nature. 1994; 369(6480): 455-61. PubMed: 8202136
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| Comments |
SwissProt and NCBI have a sequence of 165 amino acids. This includes a 20 amino acid signal region on the N-terminal.
Unigene, Hs.446683, Hs.590955, Hs.659014, Hs.681647, Hs.719497
AV (6-15-2010) PubMed: 8202136
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