| General information | | DisProt: | DP00028 | | Name: | Eukaryotic translation initiation factor 4E-binding protein 1 | | Synonym(s): | 4EBP1_HUMAN
eIF4E-binding protein 1
4E-binding protein 1
4E-BP1
Phosphorylated heat- and acid-stable protein regulated by insulin 1
PHAS-I
| | First appeared in release: | Release 1.0 (08/01/2003) | | UniProt: | Q13541 | | UniGene: | Hs.411641 | | SwissProt: | 4EBP1_HUMAN | | TrEMBL: | | | NCBI (GI): | 34921508 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 118 | | Percent disordered: | 100% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MSGGSSCSQT PSRAIPATRR VVLGDGVQLP PGDYSTTPGG TLFSTTPGGT RIIYDRKFLM - 60
ECRNSPVTKT PPRDLPTIPG VTSPSSDEPP MEASQSHLRN SPEDKRAGGE ESQFEMDI
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| Functional narrative |
Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 1 - 118 | | Length: | 118 | | Region sequence: |
MSGGSSCSQTPSRAIPATRRVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTRIIYDRKFLM
ECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRNSPEDKRAGGEESQFEMDI | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Function arises from the disordered state
| | Functional classes: | | | Functional subclasses: | Protein inhibitor
| Detection methods:
- Nuclear magnetic resonance (NMR) (300 K; pH: 6.5; Boehringer Mannheim protease inhibitor tablet; DTT 10 mM; EDTA 1 mM; NaCl 100 mM; NaH2P04/Na2HP04 50 mM; NaN3 0.1 mM; PMSF 0.1 mM)
| References:
- Fletcher CM, Wagner G. "The interaction of eIF4E with 4E-BP1 is an induced fit to a completely disordered protein." Protein Sci. 1998; 7(7): 1639-42. PubMed: 9684899
| Comments:
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| References |
- Fletcher CM, Wagner G. "The interaction of eIF4E with 4E-BP1 is an induced fit to a completely disordered protein." Protein Sci. 1998; 7(7): 1639-42. PubMed: 9684899
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| Comments |
AV 6-28-2010 PubMed: 9684899
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