DP00033: Growth hormone receptor [Isoform 1 (GHRfl)]FASTA viewXML view

General information
DisProt:DP00033
Name:Growth hormone receptor [Isoform 1 (GHRfl)]
Synonym(s):GHR_HUMAN
GH receptor
Somatotropin receptor
Growth hormone-binding protein [cleavage product 1]
GH-binding protein
GHBP
Serum-binding protein
First appeared in release:Release 5.1 (05/28/2010)
UniProt:P10912-1
UniGene:Hs.125180
SwissProt: GHR_HUMAN
TrEMBL:  
NCBI (GI): 121180
Source organism:Homo sapiens (Human)
Sequence length:638
Percent disordered:-1%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MDLWQLLLTL ALAGSSDAFS GSEATAAILS RAPWSLQSVN PGLKTNSSKE PKFTKCRSPE - 60
RETFSCHWTD EVHHGTKNLG PIQLFYTRRN TQEWTQEWKE CPDYVSAGEN SCYFNSSFTS - 120
IWIPYCIKLT SNGGTVDEKC FSVDEIVQPD PPIALNWTLL NVSLTGIHAD IQVRWEAPRN - 180
ADIQKGWMVL EYELQYKEVN ETKWKMMDPI LTTSVPVYSL KVDKEYEVRV RSKQRNSGNY - 240
GEFSEVLYVT LPQMSQFTCE EDFYFPWLLI IIFGIFGLTV MLFVFLFSKQ QRIKMLILPP - 300
VPVPKIKGID PDLLKEGKLE EVNTILAIHD SYKPEFHSDD SWVEFIELDI DEPDEKTEES - 360
DTDRLLSSDH EKSHSNLGVK DGDSGRTSCC EPDILETDFN ANDIHEGTSE VAQPQRLKGE - 420
ADLLCLDQKN QNNSPYHDAC PATQQPSVIQ AEKNKPQPLP TEGAESTHQA AHIQLSNPSS - 480
LSNIDFYAQV SDITPAGSVV LSPGQKNKAG MSQCDMHPEM VSLCQENFLM DNAYFCEADA - 540
KKCIPVAPHI KVESHIQPSL NQEDIYITTE SLTTAAGRPG TGEHVPGSEM PVPDYTSIHI - 600
VQSPQGLILN ATALPLPDKE FLSSCGYVST DQLNKIMP



Functional narrative    

Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.



Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Comments


Previous entry DP00033 has been split into polyprotein DP00033 and cleavage product DP00033_C001. Disorder is characterized on the cleavage product.


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