| General information | | DisProt: | DP00034 | | Name: | Attachment protein G3P | | Synonym(s): | G3P_BPFD
Gene 3 protein
G3P
Minor phage coat protein G3P
| | First appeared in release: | Release 1.0 (08/01/2003) | | UniProt: | P03661 | | UniGene: | | | SwissProt: | G3P_BPFD | | TrEMBL: | | | NCBI (GI): | 116658 | | Source organism: | Enterobacteria phage fd (Bacteriophage fd) | | Sequence length: | 424 | | Percent disordered: | 6% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MKKLLFAIPL VVPFYSHSAE TVESCLAKPH TENSFTNVWK DDKTLDRYAN YEGCLWNATG - 60
VVVCTGDETQ CYGTWVPIGL AIPENEGGGS EGGGSEGGGS EGGGTKPPEY GDTPIPGYTY - 120
INPLDGTYPP GTEQNPANPN PSLEESQPLN TFMFQNNRFR NRQGALTVYT GTVTQGTDPV - 180
KTYYQYTPVS SKAMYDAYWN GKFRDCAFHS GFNEDPFVCE YQGQSSDLPQ PPVNAGGGSG - 240
GGSGGGSEGG GSEGGGSEGG GSEGGGSGGG SGSGDFDYEK MANANKGAMT ENADENALQS - 300
DAKGKLDSVA TDYGAAIDGF IGDVSGLANG NGATGDFAGS NSQMAQVGDG DNSPLMNNFR - 360
QYLPSLPQSV ECRPYVFGAG KPYEFSIDCD KINLFRGVFA FLLYVATFMY VFSTFANILR - 420
NKES
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| Functional narrative |
Plays essential roles both in the entry of the viral genome into the bacterial host and in the budding process. During the initial step of infection, G3P mediates adsorption of the phage to its primary receptor, the tip of host F-pilus. Subsequent interaction with the host coreceptor tolA induces penetration of the viral DNA into the host cytoplasm. In the budding process, G3P mediates the release of the membrane-anchored virion from the cell via its C-terminal domain.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | linker | | Location: | 67 - 90 | | Length: | 24 | | Region sequence: |
DETQCYGTWVPIGLAIPENEGGGS | | Modification type: | Native
| | PDB: | 1G3P:A | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | Flexible linkers/spacers
| Detection methods:
- X-ray crystallography (100 K; wavelength 0.947 A)
| References:
- Holliger P, Riechmann L, Williams RL. "Crystal structure of the two N-terminal domains of g3p from filamentous phage fd at 1.9 A: evidence for conformational lability." J Mol Biol. 1999; 288(4): 649-57. PubMed: 10329170
- Nilsson N, Malmborg AC, Borrebaeck CA. "The phage infection process: a functional role for the distal linker region of bacteriophage protein 3." J Virol. 2000; 74(9): 4229-35. PubMed: 10756036
| Comments:
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| References |
- Nilsson N, Malmborg AC, Borrebaeck CA. "The phage infection process: a functional role for the distal linker region of bacteriophage protein 3." J Virol. 2000; 74(9): 4229-35. PubMed: 10756036
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| Comments |
AV 6-28-2010 PubMed: 10756036
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