DP00038: Non-histone chromosomal protein HMG-14FASTA viewXML view

General information
DisProt:DP00038
Name:Non-histone chromosomal protein HMG-14
Synonym(s):HMGN1_BOVIN
High-mobility group nucleosome-binding domain-containing protein 1
First appeared in release:Release 2.0 (02/14/2005)
UniProt:P02316
UniGene:Bt.87121
SwissProt: HMGN1_BOVIN
TrEMBL:  
NCBI (GI): 108935921
Source organism:Bos taurus (Bovine)
Sequence length:100
Percent disordered:99%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
PKRKVSSAEG AAKEEPKRRS ARLSAKPAPA KVETKPKKAA GKDKSSDKKV QTKGKRGAKG - 60
KQAEVANQET KEDLPAENGE TKNEESPASD EAEEKEAKSD



Functional narrative    

Nonhistone chromosomal protein HMG-14 belongs to the HMG-14/HMG-17 protein family. It was shown by CD and NMR that HMG-14 does not form secondary or tertiary structure in solution. The conformation when bound to the inner side of nucleosomes is dependent on its binding to other components of the histone-DNA complex.

Region 1: 1-99

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered - Extended
Name: 
Location:1 - 99
Length:99
Region sequence:

PKRKVSSAEGAAKEEPKRRSARLSAKPAPAKVETKPKKAAGKDKSSDKKVQTKGKRGAKG
KQAEVANQETKEDLPAENGETKNEESPASDEAEEKEAKS

Modification type: Native
PDB:  
Structural/functional type: Function arises from the disordered state
Function arises via a disorder to order transition
Functional classes: Molecular recognition effectors
Molecular assembly
Functional subclasses: Phosphorylation
Protein-DNA binding
Acetylation
Protein-protein binding
Detection methods:
  1. Circular dichroism (CD) spectroscopy, far-UV

  2. Nuclear magnetic resonance (NMR)

  3. Fourier transform infrared spectroscopy (FTIR), aka infrared spectroscopy)
References:
  1. Cary PD, Crane-Robinson C, Bradbury EM, Dixon GH. "Structural studies of the non-histone chromosomal proteins HMG-T and H6 from trout testis." Eur J Biochem. 1981; 119(3): 545-51. PubMed: 6273163
Comments:
 


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