DP00042: Non-histone chromosomal protein H6FASTA viewXML view

General information
DisProt:DP00042
Name:Non-histone chromosomal protein H6
Synonym(s):H6_ONCMY
Histone T
High mobility group H6
Oncorhyncin-3 [cleavage product 1]
Oncorhyncin III
First appeared in release:Release 2.0 (02/14/2005)
UniProt:P02315
UniGene: 
SwissProt: H6_ONCMY
TrEMBL:  
NCBI (GI): 462245
Source organism:Oncorhynchus mykiss (Rainbow trout)(Salmo gairdneri)
Sequence length:70
Percent disordered:99%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MPKRKSATKG DEPARRSARL SARPVPKPAA KPKKAAAPKK AVKGKKAAEN GDAKAEAKVQ - 60
AAGDGAGNAK



Functional narrative    

Non-histone protein that probably binds to the inner side of nucleosomal DNA, altering the association between the DNA and the nucleosome octamer.

Region 1: 2-70

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered - Extended
Name: 
Location:2 - 70
Length:69
Region sequence:

PKRKSATKGDEPARRSARLSARPVPKPAAKPKKAAAPKKAVKGKKAAENGDAKAEAKVQA
AGDGAGNAK

Modification type:  
PDB:  
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Molecular assembly
Functional subclasses: Protein-DNA binding
Detection methods:
  1. Circular dichroism (CD) spectroscopy, far-UV

  2. Nuclear magnetic resonance (NMR)

References:
  1. Cary PD, Crane-Robinson C, Bradbury EM, Dixon GH. "Structural studies of the non-histone chromosomal proteins HMG-T and H6 from trout testis." Eur J Biochem. 1981; 119(3): 545-51. PubMed: 6273163

Comments:
 



Comments


Disordered residues lie within the region corresponding to Oncorhyncin III, however, there are no references to confirm that the cleavage product is disordered.


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