| General information | | DisProt: | DP00045 | | Name: | Hypoxanthine-guanine phosphoribosyltransferase | | Synonym(s): | Q27796_TRYCR
HGPRTase
Guanine phosphoribosyltransferase
Hypoxanthine phosphoribosyltransferase
HPRT
IMP diphosphorylase
IMP pyrophosphorylase
Transphosphoribosidase
| | First appeared in release: | Release 1.0 (08/01/2003) | | UniProt: | Q27796 | | UniGene: | | | SwissProt: | Q27796_TRYCR | | TrEMBL: | | | NCBI (GI): | 74967377 | | Source organism: | Trypanosoma cruzi | | Sequence length: | 220 | | Percent disordered: | 14% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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PREYEFAEKI LFTEEEIRTR IKEVAKRIAD DYKGKGLRPY VNPLVLISVL KGSFMFTADL - 60
CRALCDFNVP VRMEFICVSS YGEGLTSSGQ VRMLLDTRHS IEGHHVLIVE DIVDTALTLN - 120
YLYHMYFTRR PASLKTVVLL DKREGRRVPF SADYVVANIP NAFVIGYGLD YDDTYRELRD - 180
IVVLRPEVYA EREAARQKKQ RAIGSADTDR DAKREFHSKY
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| Functional narrative |
Hypoxanthine-guanine phosphoribosyltransferase (HPRT) belongs to the family of phosphoribosyltransferases (PRTs) which catalyze the transfer of the ribose 5’-phosphate group from 5’-phosphoribosyl-alpha-1’-pyrophosphate (PRPP) to a variety of secondary substrates in a salvage pathway to obtain purine nucleotides for cellular metabolism. The HPRT active-site loop is linked directly to the other subunit as part of a mechanism that is believed to provide method for communication between units of the functional dimmer.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered - Extended | | Name: | | | Location: | 191 - 220 | | Length: | 30 | | Region sequence: |
EREAARQKKQRAIGSADTDRDAKREFHSKY | | Modification type: | | | PDB: | 1TC1:A | | Structural/functional type: | Relationship to function unknown
| | Functional classes: | Unknown
| | Functional subclasses: | Unknown
| Detection methods:
- X-ray crystallography
| References:
- Focia PJ, Craig SP 3rd, Nieves-Alicea R, Fletterick RJ, Eakin AE. "A 1.4 A crystal structure for the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi." Biochemistry. 1998; 37(43): 15066-15075. PubMed: 9790669
| Comments:
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| Region 2 | | Type: | Ordered | | Name: | | | Location: | 5 - 190 | | Length: | 186 | | Region sequence: |
EFAEKILFTEEEIRTRIKEVAKRIADDYKGKGLRPYVNPLVLISVLKGSFMFTADLCRAL
CDFNVPVRMEFICVSSYGEGLTSSGQVRMLLDTRHSIEGHHVLIVEDIVDTALTLNYLYH
MYFTRRPASLKTVVLLDKREGRRVPFSADYVVANIPNAFVIGYGLDYDDTYRELRDIVVL
RPEVYA | | Modification type: | | | PDB: | | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
| References:
- Focia PJ, Craig SP 3rd, Nieves-Alicea R, Fletterick RJ, Eakin AE. "A 1.4 A crystal structure for the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi." Biochemistry. 1998; 37(43): 15066-15075. PubMed: 9790669
| Comments:
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| Comments |
This is subunit I of the protein.
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| If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
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