| General information | | DisProt: | DP00049 | | Name: | Myelin transcription factor 1-like protein | | Synonym(s): | MYT1L_RAT
MyT1L protein
Neural zinc finger factor 1
NZF-1
| | First appeared in release: | Release 1.0 (08/01/2003) | | UniProt: | P70475 | | UniGene: | Rn.10559 | | SwissProt: | MYT1L_RAT | | TrEMBL: | | | NCBI (GI): | 76363255 | | Source organism: | Rattus norvegicus (Rat) | | Sequence length: | 1187 | | Percent disordered: | 10% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MDVDAEEKRH RTRSKGVRVP VEPAIQELFS CPTPGCDGTG HVSGKYARHR SVYGCPLAKK - 60
RKTQDKQPQE PAPKRKPFAV KADSSSVDEC YESDGTEDMD DKEEDDDEEF SEDNDEQGDD - 120
DDEDEVDRED EEEIEEEDDE DDEDDDDGDD VEEEEDDDDE EEEEEEEEEE NEDHQMSCTR - 180
IMQDPEKDDN NNDEYDNYDE LVAKSLLNLG KIAEDAAYRA RTESEVNSNT SNSLEDHSSK - 240
NENLGRKSEL SLDLDSDVVR ETVDSLKLLA QGHGVVLSEN ISDRSYAEGM SQQDSRNMNY - 300
VMLGKPMNNG LMEKMVEESD EEVCLSSLEC LRNQCFDLAR KLSETNPQDR SQPPNMSVRQ - 360
HVRQEDDFPG RTPDRSYSDM MNLMRLEEQL SPRSRTFSSC AKEDGCHERD DDTTTVNSDR - 420
SEEVFDMTKG NLTLLEKAIA LETERAKAMR EKMAMDAGRR DNLRSYEDQS PRQLAGEDRK - 480
SKSSDSHVKK PYYDPSRTEK RESKCPTPGC DGTGHVNGLY PHHRSLSGCP HKDRVPPEIL - 540
AMHENVLKCP TPGCTGRGHV NSNRNSHRSL SGCPIAAAEK LAKAQEKHQS CDVSKSNQAS - 600
DRVLRPMCFV KQLEIPQYGY RNNVPTTTPR SNLAKELEKY SKTSFEYNSY DNHTYGKRAI - 660
APRCKPGTYP PKDMTMPSGT GKNASPSSST TSSYAPSSSS NLSCGGGSSA SSTCSKSSFD - 720
YTHDMEAAHM AATAILNLST RCREMPQNLS TKPQDLCTAR NPDMEVDENG TLDLSMNKQR - 780
PRDSCCPVLT PLEPMSPQQQ AVMSSRCFQL SEGDCWDLPV DYTKMKPRRV DEEDPKEITP - 840
EDLDPFQEAL EERRYPGEVT IPSPKPKYPQ CKESKKDLIT LSGCPLADKS IRSMLATSSQ - 900
ELKCPTPGCD GSGHITGNYA SHRSLSGCPR AKKSGIRIAQ SKEDKEDQEP IRCPVPGCDG - 960
QGHITGKYAS HRSASGCPLA AKRQKDGYLN GSQFSWKSVK TEGMSCPTPG CDGSGHVSGS - 1020
FLTHRSLSGC PRATSAMKKA KLSGEQMLTI KQRASNGIEN DEEIKQLDEE IKELNESNSQ - 1080
MEADMIKLRT QVTITTMESN LKTIEEENKV IEQQNESLLH ELANLSQSLI HSLANIQLPH - 1140
MDPINEQNFD AYVTTLTEMY TNQDRYQSPE NKALLENIKQ AVRGIQV
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| Functional narrative |
Neural zinc finger factor-1 (NFZ-1) is a member of the neural-specific transcription factor family. NZF-1 is has distinct temporal and spatial patterns in developing nervous systems of Rattus norvegicus. Regulatory roles are carried out by NZF-1 in spinal cord, sensory ganglia, retina, nasal epithelia, and testis with high expression in brain and pituitary. Transcription is activated from promoters containing specific binding sequences. NZF-1 can also synergize with other factors (e.g., Pit 1) to regulate gene espression. Neural zinc finger factor-1 contains six Cys-Cys and His-Cys zinc fingers.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered - Extended | | Name: | zinc binding domains | | Location: | 487 - 606 | | Length: | 120 | | Region sequence: |
HVKKPYYDPSRTEKRESKCPTPGCDGTGHVNGLYPHHRSLSGCPHKDRVPPEILAMHENV
LKCPTPGCTGRGHVNSNRNSHRSLSGCPIAAAEKLAKAQEKHQSCDVSKSNQASDRVLRP
| | Modification type: | Complex
Fragment
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Molecular recognition effectors
| | Functional subclasses: | Metal binding
Transactivation (transcriptional activation)
Protein-DNA binding
| Detection methods:
- Nuclear magnetic resonance (NMR)
- SDS-PAGE gel, Aberrant mobility on (+/- Zn)
| References:
- Berkovits HJ, Berg JM. "Metal and DNA binding properties of a two-domain fragment of neural zinc finger factor 1, a CCHC-type zinc binding protein." Biochemistry. 1999; 38(51): 16826-30. PubMed: 10606515
| Comments:
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| References |
- Jiang Y, Yu VC, Buchholz F, O'Connell S, Rhodes SJ, Candeloro C, Xia YR, Lusis AJ, Rosenfeld MG. "A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland." J Biol Chem. 1996; 271(18): 10723-10730. PubMed: 8631881
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