DP00053: Phenylalanyl-tRNA synthetase alpha chainFASTA viewXML view

General information
DisProt:DP00053
Name:Phenylalanyl-tRNA synthetase alpha chain
Synonym(s):SYFA_THETH
Phenylalanine--tRNA ligase alpha chain
PheRS
Phenylalanine translase
EC=6.1.1.20
First appeared in release:Release 1.0 (08/01/2003)
UniProt:P27001
UniGene: 
SwissProt: SYFA_THETH
TrEMBL:  
NCBI (GI): 135112
Source organism:Thermus thermophilus
Sequence length:350
Percent disordered:24%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MLEEALAAIQ NARDLEELKA LKARYLGKKG LLTQEMKGLS ALPLEERRKR GQELNAIKAA - 60
LEAALEAREK ALEEAALKEA LERERVDVSL PGASLFSGGL HPITLMEREL VEIFRALGYQ - 120
AVEGPEVESE FFNFDALNIP EHHPARDMWD TFWLTGEGFR LEGPLGEEVE GRLLLRTHTS - 180
PMQVRYMVAH TPPFRIVVPG RVFRFEQTDA THEAVFHQLE GLVVGEGIAM AHLKGAIYEL - 240
AQALFGPDSK VRFQPVYFPF VEPGAQFAVW WPEGGKWLEL GGAGMVHPKV FQAVDAYRER - 300
LGLPPAYRGV TGFAFGLGVE RLAMLRYGIP DIRYFFGGRL KFLEQFKGVL

Region 1: 1-85

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:N-terminal
Location:1 - 85
Length:85
Region sequence:

MLEEALAAIQNARDLEELKALKARYLGKKGLLTQEMKGLSALPLEERRKRGQELNAIKAA
LEAALEAREKALEEAALKEALERER

Modification type: Complex
PDB: 1PYS:A, 1PYS:B
Structural/functional type: Function arises via a disorder to order transition
Functional classes:  
Functional subclasses: Protein-tRNA binding
Substrate/ligand binding
Detection methods:
  1. X-ray crystallography (MAR Research (image plate detector); resolution 2.9 A; Rigaku RU-300 (rotating anode generator); Xentronics (area detector))
References:
  1. Goldgur Y, Mosyak L, Reshetnikova L, Ankilova V, Lavrik O, Khodyreva S, Safro M. "The crystal structure of phenylalanyl-tRNA synthetase from thermus thermophilus complexed with cognate tRNAPhe." Structure. 1997; 5(1): 59-68. PubMed: 9016717

  2. Mosyak L, Reshetnikova L, Goldgur Y, Delarue M, Safro MG. "Structure of phenylalanyl-tRNA synthetase from Thermus thermophilus." Nat Struct Biol. 1995; 2(7): 537-47. PubMed: 7664121
Comments:
 



References

  1. Mosyak L, Reshetnikova L, Goldgur Y, Delarue M, Safro MG. "Structure of phenylalanyl-tRNA synthetase from Thermus thermophilus." Nat Struct Biol. 1995; 2(7): 537-47. PubMed: 7664121



Comments


AV 6-28-2010 PubMed: 7664121


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