DP00063: Regulator of G-protein signaling 4FASTA viewXML view

General information
DisProt:DP00063
Name:Regulator of G-protein signaling 4
Synonym(s):RGS4_RAT
RGS4
RGP4
Signal transduction inhibitor RGS4
First appeared in release:Release 1.0 (08/01/2003)
UniProt:P49799
UniGene:Rn.11065
SwissProt: RGS4_RAT
TrEMBL:  
NCBI (GI): 1710149
Source organism:Rattus norvegicus (Rat)
Sequence length:205
Percent disordered:38%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHSSSHS KKDKVVTCQR VSQEEVKKWA - 60
ESLENLINHE CGLAAFKAFL KSEYSEENID FWISCEEYKK IKSPSKLSPK AKKIYNEFIS - 120
VQATKEVNLD SCTREETSRN MLEPTITCFD EAQKKIFNLM EKDSYRRFLK SRFYLDLTNP - 180
SSCGAEKQKG AKSSADCTSL VPQCA

Region 1: 1-50 Region 2: 179-205

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:1 - 50
Length:50
Region sequence:

MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHSSSHSKKDKVVTCQR

Modification type: Native
PDB:  
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Molecular recognition effectors
Functional subclasses: Substrate/ligand binding
Detection methods:
  1. X-ray crystallography (pH: 5.3; AlCl3 140 uM; DTT (fresh) 5 mM; NaF 70 mM; PEG 10K (w/v) 14.4 %; sodium citrate 100 mM)
References:
  1. Tesmer JJ, Berman DM, Gilman AG, Sprang SR. "Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis." Cell. 1997; 89(2): 251-61. PubMed: 9108480
Comments:
 



Region 2
Type:Disordered
Name: 
Location:179 - 205
Length:27
Region sequence:

NPSSCGAEKQKGAKSSADCTSLVPQCA

Modification type: Native
PDB:  
Structural/functional type:  
Functional classes: Molecular recognition effectors
Functional subclasses: Substrate/ligand binding
Detection methods:
  1. X-ray crystallography (pH: 5.3; AlCl3 140 uM; DTT (fresh) 5 mM; NaF 70 mM; PEG 10K (w/v) 14.4 %; sodium citrate 100 mM)
References:
  1. Tesmer JJ, Berman DM, Gilman AG, Sprang SR. "Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis." Cell. 1997; 89(2): 251-61. PubMed: 9108480
Comments:
 



References

  1. Chatterjee TK, Fisher RA. "Novel alternative splicing and nuclear localization of human RGS12 gene products." J Biol Chem. 2000; 275(38): 29660-71. PubMed: 10869340

  2. Moy FJ, Chanda PK, Cockett MI, Edris W, Jones PG, Mason K, Semus S, Powers R. "NMR structure of free RGS4 reveals an induced conformational change upon binding Galpha." Biochemistry. 2000; 39(24): 7063-73. PubMed: 10852703


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