| General information | | DisProt: | DP00072 | | Name: | Titin | | Synonym(s): | TITIN_HUMAN
EC=2.7.11.1
Connectin
Rhabdomyosarcoma antigen MU-RMS-40.14
Elastic-titin skeletal [fragment]
| | First appeared in release: | Release 1.0 (08/01/2003) | | UniProt: | Q8WZ42-1 | | UniGene: | Hs.134602 | | SwissProt: | TITIN_HUMAN | | TrEMBL: | | | NCBI (GI): | 108861911 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 7962 | | Percent disordered: | 27% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
| | | | | |
PDQEMPVYPP AIITPLQDTV TSEGQPARFQ CRVSGTDLKV SWYSKDKKIK PSRFFRMTQF - 60
EDTYQLEIAE AYPEDEGTYT FVANNAVGQV SSTANLSLEA PESILHERIE QEIEMEMKAA - 120
PVIKRKIEPL EVALGHLAKF TCEIQSAPNV RFQWFKAGRE IYESDKCSIR SSKYISSLEI - 180
LRTQVVDCGE YTCKASNEYG SVSCTATLTV TEAYPPTFLS RPKSLTTFVG KAAKFICTVT - 240
GTPVIETIWQ KDGAALSPSP NWRISDAENK HILELSNLTI QDRGVYSCKA SNKFGADICQ - 300
AELIIIDKPH FIKELEPVQS AINKKVHLEC QVDEDRKVTV TWSKDGQKLP PGKDYKICFE - 360
DKIATLEIPL AKLKDSGTYV CTASNEAGSS SCSATVTVRE PPSFVKKVDP SYLMLPGESA - 420
RLHCKLKGSP VIQVTWFKNN KELSESNTVR MYFVNSEAIL DITDVKVEDS GSYSCEAVND - 480
VGSDSCSTEI VIKEPPSFIK TLEPADIVRG TNALLQCEVS GTGPFEISWF KDKKQIRSSK - 540
KYRLFSQKSL VCLEIFSFNS ADVGEYECVV ANEVGKCGCM ATHLLKEPPT FVKKVDDLIA - 600
LGGQTVTLQA AVRGSEPISV TWMKGQEVIR EDGKIKMSFS NGVAVLIIPD VQISFGGKYT - 660
CLAENEAGSQ TSVGELIVKE PAKIIERAEL IQVTAGDPAT LEYTVAGTPE LKPKWYKDGR - 720
PLVASKKYRI SFKNNVAQLK FYSAELHDSG QYTFEISNEV GSSSCETTFT VLDRDIAPFF - 780
TKPLRNVDSV VNGTCRLDCK IAGSLPMRVS WFKDGKEIAA SDRYRIAFVE GTASLEIIRV - 840
DMNDAGNFTC RATNSVGSKD SSGALIVQEP PSFVTKPGSK DVLPGSAVCL KSTFQGSTPL - 900
TIRWFKGNKE LVSGGSCYIT KEALESSLEL YLVKTSDSGT YTCKVSNVAG GVECSANLFV - 960
KEPATFVEKL EPSQLLKKGD ATQLACKVTG TPPIKITWFA NDREIKESSK HRMSFVESTA - 1020
VLRLTDVGIE DSGEYMCEAQ NEAGSDHCSS IVIVKESPYF TKEFKPIEVL KEYDVMLLAE - 1080
VAGTPPFEIT WFKDNTILRS GRKYKTFIQD HLVSLQILKF VAADAGEYQC RVTNEVGSSI - 1140
CSARVTLREP PSFIKKIEST SSLRGGTAAF QATLKGSLPI TVTWLKDSDE ITEDDNIRMT - 1200
FENNVASLYL SGIEVKHDGK YVCQAKNDAG IQRCSALLSV KEPATITEEA VSIDVTQGDP - 1260
ATLQVKFSGT KEITAKWFKD GQELTLGSKY KISVTDTVSI LKIISTEKKD SGEYTFEVQN - 1320
DVGRSSCKAR INVLDLIIPP SFTKKLKKMD SIKGSFIDLE CIVAGSHPIS IQWFKDDQEI - 1380
SASEKYKFSF HDNTAFLEIS QLEGTDSGTY TCSATNKAGH NQCSGHLTVK EPPYFVEKPQ - 1440
SQDVNPNTRV QLKALVGGTA PMTIKWFKDN KELHSGAARS VWKDDTSTSL ELFAAKATDS - 1500
GTYICQLSND VGTATSKATL FVKEPPQFIK KPSPVLVLRN GQSTTFECQI TGTPKIRVSW - 1560
YLDGNEITAI QKHGISFIDG LATFQISGAR VENSGTYVCE ARNDAGTASC SIELKVKEPP - 1620
TFIRELKPVE VVKYSDVELE CEVTGTPPFE VTWLKNNREI RSSKKYTLTD RVSVFNLHIT - 1680
KCDPSDTGEY QCIVSNEGGS CSCSTRVALK EPPSFIKKIE NTTTVLKSSA TFQSTVAGSP - 1740
PISITWLKDD QILDEDDNVY ISFVDSVATL QIRSVDNGHS GRYTCQAKNE SGVERCYAFL - 1800
LVQEPAQIVE KAKSVDVTEK DPMTLECVVA GTPELKVKWL KDGKQIVPSR YFSMSFENNV - 1860
ASFRIQSVMK QDSGQYTFKV ENDFGSSSCD AYLRVLDQNI PPSFTKKLTK MDKVLGSSIH - 1920
MECKVSGSLP ISAQWFKDGK EISTSAKYRL VCHERSVSLE VNNLELEDTA NYTCKVSNVA - 1980
GDDACSGILT VKEPPSFLVK PGRQQAIPDS TVEFKAILKG TPPFKIKWFK DDVELVSGPK - 2040
CFIGLEGSTS FLNLYSVDAS KTGQYTCHVT NDVGSDSCTT MLLVTEPPKF VKKLEASKIV - 2100
KAGDSSRLEC KIAGSPEIRV VWFRNEHELP ASDKYRMTFI DSVAVIQMNN LSTEDSGDFI - 2160
CEAQNPAGST SCSTKVIVKE PPVFSSFPPI VETLKNAEVS LECELSGTPP FEVVWYKDKR - 2220
QLRSSKKYKI ASKNFHTSIH ILNVDTSDIG EYHCKAQNEV GSDTCVCTVK LKEPPRFVSK - 2280
LNSLTVVAGE PAELQASIEG AQPIFVQWLK EKEEVIRESE NIRITFVENV ATLQFAKAEP - 2340
ANAGKYICQI KNDGGMRENM ATLMVLEPAV IVEKAGPMTV TVGETCTLEC KVAGTPELSV - 2400
EWYKDGKLLT SSQKHKFSFY NKISSLRILS VERQDAGTYT FQVQNNVGKS SCTAVVDVSD - 2460
RAVPPSFTRR LKNTGGVLGA SCILECKVAG SSPISVAWFH EKTKIVSGAK YQTTFSDNVC - 2520
TLQLNSLDSS DMGNYTCVAA NVAGSDECRA VLTVQEPPSF VKEPEPLEVL PGKNVTFTSV - 2580
IRGTPPFKVN WFRGARELVK GDRCNIYFED TVAELELFNI DISQSGEYTC VVSNNAGQAS - 2640
CTTRLFVKEP AAFLKRLSDH SVEPGKSIIL ESTYTGTLPI SVTWKKDGFN ITTSEKCNIV - 2700
TTEKTCILEI LNSTKRDAGQ YSCEIENEAG RDVCGALVST LEPPYFVTEL EPLEAAVGDS - 2760
VSLQCQVAGT PEITVSWYKG DTKLRPTPEY RTYFTNNVAT LVFNKVNIND SGEYTCKAEN - 2820
SIGTASSKTV FRIQERQLPP SFARQLKDIE QTVGLPVTLT CRLNGSAPIQ VCWYRDGVLL - 2880
RDHENLQTSF VDNVATLKIL QTDLSHSGQY SCSASNPLGT ASSSARLTAR EPKKSPFFDI - 2940
KPVSIDVIAG ESADFECHVT GAQPMRITWS KDNKEIRPGG NYTITCVGNT PHLRILKVGK - 3000
GDSGQYTCQA TNDVGKDMCS AQLSVKEPPK FVKKLEASKV AKQGESIQLE CKISGSPEIK - 3060
VSWFRNDSEL HESWKYNMSF INSVALLTIN EASAEDSGDY ICEAHNGVGD ASCSTALTVK - 3120
APPVFTQKPS PVGALKGSDV ILQCEISGTP PFEVVWVKDR KQVRNSKKFK ITSKHFDTNL - 3180
HILNLEASDV GEYHCKATNE VGSDTCSCSV KFKEPPRFVK KLSDTSTLIG DAVELRAIVE - 3240
GFQPISVVWL KDRGEVIRES ENTRISFIDN IATLQLGSPE ASNSGKYICQ IKNDAGMREC - 3300
SAVLTVLEPA RIIEKPEPMT VTTGNPFALE CVVTGTPELS AKWFKDGREL SADSKHHITF - 3360
INKVASLKIP CAEMSDKGLY SFEVKNSVGK SNCTVSVHVS DRIVPPSFIR KLKDVNAILG - 3420
ASVVLECRVS GSAPISVGWF QDGNEIVSGP KCQSSFSENV CTLNLSLLEP SDTGIYTCVA - 3480
ANVAGSDECS AVLTVQEPPS FEQTPDSVEV LPGMSLTFTS VIRGTPPFKV KWFKGSRELV - 3540
PGESCNISLE DFVTELELFE VQPLESGDYS CLVTNDAGSA SCTTHLFVKE PATFVKRLAD - 3600
FSVETGSPIV LEATYTGTPP ISVSWIKDEY LISQSERCSI TMTEKSTILE ILESTIEDYA - 3660
QYSCLIENEA GQDICEALVS VLEPPYFIEP LEHVEAVIGE PATLQCKVDG TPEIRISWYK - 3720
EHTKLRSAPA YKMQFKNNVA SLVINKVDHS DVGEYSCKAD NSVGAVASSA VLVIKARKLP - 3780
PFFARKLKDV HETLGFPVAF ECRINGSEPL QVSWYKDGVL LKDDANLQTS FVHNVATLQI - 3840
LQTDQSHIGQ YNCSASNPLG TASSSAKLIL SEHEVPPFFD LKPVSVDLAL GESGTFKCHV - 3900
TGTAPIKITW AKDNREIRPG GNYKMTLVEN TATLTVLKVG KGDAGQYTCY ASNIAGKDSC - 3960
SAQLGVQEPP RFIKKLEPSR IVKQDEFTRY ECKIGGSPEI KVLWYKDETE IQESSKFRMS - 4020
FVDSVAVLEM HNLSVEDSGD YTCEAHNAAG SASSSTSLKV KEPPIFRKKP HPIETLKGAD - 4080
VHLECELQGT PPFHVSWYKD KRELRSGKKY KIMSENFLTS IHILNVDAAD IGEYQCKATN - 4140
DVGSDTCVGS IALKAPPRFV KKLSDISTVV GKEVQLQTTI EGAEPISVVW FKDKGEIVRE - 4200
SDNIWISYSE NIATLQFSRV EPANAGKYTC QIKNDAGMQE CFATLSVLEP ATIVEKPESI - 4260
KVTTGDTCTL ECTVAGTPEL STKWFKDGKE LTSDNKYKIS FFNKVSGLKI INVAPSDSGV - 4320
YSFEVQNPVG KDSCTASLQV SDRTVPPSFT RKLKETNGLS GSSVVMECKV YGSPPISVSW - 4380
FHEGNEISSG RKYQTTLTDN TCALTVNMLE ESDSGDYTCI ATNMAGSDEC SAPLTVREPP - 4440
SFVQKPDPMD VLTGTNVTFT SIVKGTPPFS VSWFKGSSEL VPGDRCNVSL EDSVAELELF - 4500
DVDTSQSGEY TCIVSNEAGK ASCTTHLYIK APAKFVKRLN DYSIEKGKPL ILEGTFTGTP - 4560
PISVTWKKNG INVTPSQRCN ITTTEKSPIL EIPSSTVEDA GQYNCYIENA SGKDSCSAQI - 4620
LILEPPYFVK QLEPVKVSVG DSASLQCQLA GTPEIGVSWY KGDTKLRPTT TYKMHFRNNV - 4680
ATLVFNQVDI NDSGEYICKA ENSVGEVSAS TFLTVQEQKL PPSFSRQLRD VQETVGLPVV - 4740
FDCAISGSEP ISVSWYKDGK PLKDSPNVQT SFLDNTATLN IFKTDRSLAG QYSCTATNPI - 4800
GSASSSARLI LTEGKNPPFF DIRLAPVDAV VGESADFECH VTGTQPIKVS WAKDSREIRS - 4860
GGKYQISYLE NSAHLTVLKV DKGDSGQYTC YAVNEVGKDS CTAQLNIKER LIPPSFTKRL - 4920
SETVEETEGN SFKLEGRVAG SQPITVAWYK NNIEIQPTSN CEITFKNNTL VLQVRKAGMN - 4980
DAGLYTCKVS NDAGSALCTS SIVIKEPKKP PVFDQHLTPV TVSEGEYVQL SCHVQGSEPI - 5040
RIQWLKAGRE IKPSDRCSFS FASGTAVLEL RDVAKADSGD YVCKASNVAG SDTTKSKVTI - 5100
KDKPAVAPAT KKAAVDGRLF FVSEPQSIRV VEKTTATFIA KVGGDPIPNV KWTKGKWRQL - 5160
NQGGRVFIHQ KGDEAKLEIR DTTKTDSGLY RCVAFNEHGE IESNVNLQVD ERKKQEKIEG - 5220
DLRAMLKKTP ILKKGAGEEE EIDIMELLKN VDPKEYEKYA RMYGITDFRG LLQAFELLKQ - 5280
SQEEETHRLE IEEIERSERD EKEFEELVSF IQQRLSQTEP VTLIKDIENQ TVLKDNDAVF - 5340
EIDIKINYPE IKLSWYKGTE KLEPSDKFEI SIDGDRHTLR VKNCQLKDQG NYRLVCGPHI - 5400
ASAKLTVIEP AWERHLQDVT LKEGQTCTMT VQFSVPNVKS EWFRNGRILK PQGRHKTEVE - 5460
HKVHKLTIAD VRAEDQGQYT CKYEDLETSA ELRIEAEPIQ FTKRIQNIVV SEHQSATFEC - 5520
EVSFDDAIVT WYKGPTELTE SQKYNFRNDG RCHYMTIHNV TPDDEGVYSV IARLEPRGEA - 5580
RSTAELYLTT KEIKLELKPP DIPDSRVPIP TMPIRAVPPE EIPPVVAPPV PLLLPTPEEK - 5640
KPPPKRIEVT KKAVKKDAKK VVAKPKEMTP REEIVKKPPP PTTLIPAKAP EIIDVSSKAE - 5700
EVKIMTITRK KEVQKEKEAV YEKKQAVHKE KRVFIESFEE PYDELEVEPY TEPFEQPYYE - 5760
EPDEDYEEIK VEAKKEVHEE WEEDFEEGQE YYEREEGYDE GEEEWEEAYQ EREVIQVQKE - 5820
VYEESHERKV PAKVPEKKAP PPPKVIKKPV IEKIEKTSRR MEEEKVQVTK VPEVSKKIVP - 5880
QKPSRTPVQE EVIEVKVPAV HTKKMVISEE KMFFASHTEE EVSVTVPEVQ KEIVTEEKIH - 5940
VAVSKRVEPP PKVPELPEKP APEEVAPVPI PKKVEPPAPK VPEVPKKPVP EEKKPVPVPK - 6000
KEPAAPPKVP EVPKKPVPEE KIPVPVAKKK EAPPAKVPEV QKGVVTEEKI TIVTQREESP - 6060
PPAVPEIPKK KVPEERKPVP RKEEEVPPPP KVPALPKKPV PEEKVAVPVP VAKKAPPPRA - 6120
EVSKKTVVEE KRFVAEEKLS FAVPQRVEVT RHEVSAEEEW SYSEEEEGVS ISVYREEERE - 6180
EEEEAEVTEY EVMEEPEEYV VEEKLHIISK RVEAEPAEVT ERQEKKIVLK PKIPAKIEEP - 6240
PPAKVPEAPK KIVPEKKVPA PVPKKEKVPP PKVPEEPKKP VPEKKVPPKV IKMEEPLPAK - 6300
VTEKHMQITQ EEKVLVAVTK KEAPPKARVP EEPKRAVPEE KVLKLKPKRE EEPPAKVTEF - 6360
RKRVVKEEKV SIEAPKREPQ PIKEVTIMEE KERAYTLEEE AVSVQREEEY EEYEEYDYKE - 6420
FEEYEPTEEY DQYEEYEERE YERYEEHEEY ITEPEKPIPV KPVPEEPVPT KPKAPPAKVL - 6480
KKAVPEEKVP VPIPKKLKPP PPKVPEEPKK VFEEKIHISI TKREKEQVTE PAAKVPMKPK - 6540
RVVAEEKVPV PRKEVAPPVR VPEVPKELEP EEVAFEEEVV THVEEYLVEE EEEYIHEEEE - 6600
FITEEEVVPV IPVKVPEVPR KPVPEEKKPV PVPKKKEAPP AKVPEVPKKP EEKVPVLIPK - 6660
KEKPPPAKVP EVPKKPVPEE KVPVPVPKKV EAPPAKVPEV PKKPVPEKKV PVPAPKKVEA - 6720
PPAKVPEVPK KLIPEEKKPT PVPKKVEAPP PKVPKKREPV PVPVALPQEE EVLFEEEIVP - 6780
EEEVLPEEEE VLPEEEEVLP EEEEVLPEEE EIPPEEEEVP PEEEYVPEEE EFVPEEEVLP - 6840
EVKPKVPVPA PVPEIKKKVT EKKVVIPKKE EAPPAKVPEV PKKVEEKRII LPKEEEVLPV - 6900
EVTEEPEEEP ISEEEIPEEP PSIEEVEEVA PPRVPEVIKK AVPEAPTPVP KKVEAPPAKV - 6960
SKKIPEEKVP VPVQKKEAPP AKVPEVPKKV PEKKVLVPKK EAVPPAKGRT VLEEKVSVAF - 7020
RQEVVVKERL ELEVVEAEVE EIPEEEEFHE VEEYFEEGEF HEVEEFIKLE QHRVEEEHRV - 7080
EKVHRVIEVF EAEEVEVFEK PKAPPKGPEI SEKIIPPKKP PTKVVPRKEP PAKVPEVPKK - 7140
IVVEEKVRVP EEPRVPPTKV PEVLPPKEVV PEKKVPVPPA KKPEAPPPKV PEAPKEVVPE - 7200
KKVPVPPPKK PEVPPTKVPE VPKAAVPEKK VPEAIPPKPE SPPPEVFEEP EESPSAPPKK - 7260
PEVPPVRVPE VPKEVVPEKK VPAAPPKKPE VTPVKVPEAP KEVVPEKKVP VPPPKKPEVP - 7320
PTKVPEVPKV AVPEKKVPEA IPPKPESPPP EVFEEPEEVA LEEPPAEVVE EPEPAAPPQV - 7380
TVPPKNPVPE KKAPAVVAKK PELPPVKVPE VPKEVVPEKK VPLVVPKKPE APPAKVPEVP - 7440
KEVVPEKKVA VPKKPEVPPA KVPEVPKKPV LEEKPAVPVP ERAESPPPEV YEEPEEIAPE - 7500
EEIAPEEEKP VPVAEEEEPE VPPPAVPEEP KKIIPEKKVP VIKKPEAPPP KEPEPEKVIE - 7560
KPKLKPRPPP PPPAPPKEDV KEKIFQLKAI PKKKVPENPQ VPEKVELTPL KVPGGEKKVR - 7620
KLLPERKPEP KEEVVLKSVL RKRPEEEEPK VEPKKLEKVK KPAVPEPPPP KPVEEVEVPT - 7680
VTKRERKIPE PTKVPEIKPA IPLPAPEPKP KPEAEVKTIK PPPVEPEPTP IAAPVTVPVV - 7740
GKKAEAKAPK EEAAKPKGPI KGVPKKTPSP IEAERRKLRP GSGGEKPPDE APFTYQLKAV - 7800
PLKFVKEIKD IILTESEFVG SSAIFECLVS PSTAITTWMK DGSNIRESPK HRFIADGKDR - 7860
KLHIIDVQLS DAGEYTCVLR LGNKEKTSTA KLVVEELPVR FVKTLEEEVT VVKGQPLYLS - 7920
CELNKERDVV WRKDGKIVVE KPGRIVPGVI GLMRALTIND AD
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| Functional narrative |
Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
|
| Region 1 | | Type: | Disordered | | Name: | PEVK region | | Location: | 5618 - 7791 | | Length: | 2174 | | Region sequence: |
PPEEIPPVVAPPVPLLLPTPEEKKPPPKRIEVTKKAVKKDAKKVVAKPKEMTPREEIVKK
PPPPTTLIPAKAPEIIDVSSKAEEVKIMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIES
FEEPYDELEVEPYTEPFEQPYYEEPDEDYEEIKVEAKKEVHEEWEEDFEEGQEYYEREEG
YDEGEEEWEEAYQEREVIQVQKEVYEESHERKVPAKVPEKKAPPPPKVIKKPVIEKIEKT
SRRMEEEKVQVTKVPEVSKKIVPQKPSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASH
TEEEVSVTVPEVQKEIVTEEKIHVAVSKRVEPPPKVPELPEKPAPEEVAPVPIPKKVEPP
APKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKV
PEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPK
KPVPEEKVAVPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAE
EEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPA
EVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEEP
KKPVPEKKVPPKVIKMEEPLPAKVTEKHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAV
PEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQPIKEVTIMEEKERAYTL
EEEAVSVQREEEYEEYEEYDYKEFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKP
IPVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEPKKVFEEKIH
ISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKELEPEEVAFEE
EVVTHVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKE
APPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPAKV
PEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKVPKKR
EPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEE
EVPPEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKV
PEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEVEEVAPPRVPEV
IKKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVPVPVQKKEAPPAKVPEVPKKVPEKKVLV
PKKEAVPPAKGRTVLEEKVSVAFRQEVVVKERLELEVVEAEVEEIPEEEEFHEVEEYFEE
GEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVEVFEKPKAPPKGPEISEKIIPP
KKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVLPPKEVVPEKKVPV
PPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEAIPP
KPESPPPEVFEEPEESPSAPPKKPEVPPVRVPEVPKEVVPEKKVPAAPPKKPEVTPVKVP
EAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPE
EVALEEPPAEVVEEPEPAAPPQVTVPPKNPVPEKKAPAVVAKKPELPPVKVPEVPKEVVP
EKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAV
PVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEK
KVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPE
NPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLE
KVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVK
TIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEEAAKPKGPIKGVPKKTPSPIEAERRK
LRPGSGGEKPPDEA | | Modification type: | Fragment
| | PDB: | | | Structural/functional type: | Function arises from the disordered state
| | Functional classes: | Entropic chain
| | Functional subclasses: | Entropic spring
| Detection methods:
| References:
- Labeit S, Kolmerer B. "Titins: giant proteins in charge of muscle ultrastructure and elasticity." Science. 1995; 270(5234): 293-6. PubMed: 7569978
- Trombitas K, Greaser M, Labeit S, Jin JP, Kellermayer M, Helmes M, Granzier H. "Titin extensibility in situ: entropic elasticity of permanently folded and permanently unfolded molecular segments." J Cell Biol. 1998; 140(4): 853-9. PubMed: 9472037
| Comments:
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| References |
- Helmes M, Trombitas K, Centner T, Kellermayer M, Labeit S, Linke WA, Granzier H. "Mechanically driven contour-length adjustment in rat cardiac titin's unique N2B sequence: titin is an adjustable spring." Circ Res. 1999; 84(11): 1339-52. PubMed: 10364572
- Kellermayer MS, Smith SB, Granzier HL, Bustamante C. "Folding-unfolding transitions in single titin molecules characterized with laser tweezers." Science. 1997; 276(5315): 1112-6. PubMed: 9148805
- Ma K, Kan L, Wang K. "Polyproline II helix is a key structural motif of the elastic PEVK segment of titin." Biochemistry. 2001; 40(12): 3427-38. PubMed: 11297408
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| If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
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