| General information | | DisProt: | DP00074 | | Name: | Estrogen receptor [Isoform long] | | Synonym(s): | ESR1_HUMAN
ER
Estradiol receptor
Estrogen receptor alpha
ER-alpha
Nuclear receptor subfamily 3 group A member 1
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | P03372 | | UniGene: | Hs.208124 | | SwissProt: | ESR1_HUMAN | | TrEMBL: | | | NCBI (GI): | 544257 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 595 | | Percent disordered: | 35% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA VYNYPEGAAY - 60
EFNAAAAANA QVYGQTGLPY GPGSEAAAFG SNGLGGFPPL NSVSPSPLML LHPPPQLSPF - 120
LQPHGQQVPY YLENEPSGYT VREAGPPAFY RPNSDNRRQG GRERLASTND KGSMAMESAK - 180
ETRYCAVCND YASGYHYGVW SCEGCKAFFK RSIQGHNDYM CPATNQCTID KNRRKSCQAC - 240
RLRKCYEVGM MKGGIRKDRR GGRMLKHKRQ RDDGEGRGEV GSAGDMRAAN LWPSPLMIKR - 300
SKKNSLALSL TADQMVSALL DAEPPILYSE YDPTRPFSEA SMMGLLTNLA DRELVHMINW - 360
AKRVPGFVDL TLHDQVHLLE CAWLEILMIG LVWRSMEHPG KLLFAPNLLL DRNQGKCVEG - 420
MVEIFDMLLA TSSRFRMMNL QGEEFVCLKS IILLNSGVYT FLSSTLKSLE EKDHIHRVLD - 480
KITDTLIHLM AKAGLTLQQQ HQRLAQLLLI LSHIRHMSNK GMEHLYSMKC KNVVPLYDLL - 540
LEMLDAHRLH APTSRGGASV EETDQSHLAT AGSTSSHSLQ KYYITGEAEG FPATV
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| Functional narrative |
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | N-terminal domain | | Location: | 1 - 184 | | Length: | 184 | | Region sequence: |
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRY | | Modification type: | Fragment
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | | | Functional subclasses: | Protein-protein binding
| Detection methods:
- Nuclear magnetic resonance (NMR) (283 K; pH: 5.3; NaCl 100 mM; Sodium azide (0.01%); Sodium dihydrogen phosphate 10 mM)
- Circular dichroism (CD) spectroscopy, far-UV (298 K; pH: 6; Sodium acetate 15 mM; Sodium phosphate 10 mM)
| References:
- Warnmark A, Wikstrom A, Wright AP, Gustafsson JA, Hard T. "The N-terminal regions of estrogen receptor alpha and beta are unstructured in vitro and show different TBP binding properties." J Biol Chem. 2001; 276(49): 45939-44. PubMed: 11595744
| Comments:The fragment used consisted of residues 1-184.
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| Region 2 | | Type: | Disordered | | Name: | | | Location: | 221 - 237 | | Length: | 17 | | Region sequence: |
CPATNQCTIDKNRRKSC | | Modification type: | Fragment
Monomeric
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Molecular assembly
| | Functional subclasses: | Protein-DNA binding
Protein-protein binding
| Detection methods:
- Nuclear magnetic resonance (NMR) (pH: 6.5; 2H2O; sodium pyrophosphate 40 mM; ZnSO4 50 mM)
- Nuclear magnetic resonance (NMR) (pH: 6.5; H2O/2H2O (85/15%); sodium pyrophosphate 40 mM; ZnSO4 50 mM)
| References:
- Schwabe JW, Chapman L, Finch JT, Rhodes D, Neuhaus D. "DNA recognition by the oestrogen receptor: from solution to the crystal." Structure. 1993; 1(3): 187-204. PubMed: 16100953
| Comments:
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| Region 3 | | Type: | Disordered | | Name: | ERDBD C-terminus | | Location: | 253 - 262 | | Length: | 10 | | Region sequence: |
GGIRKDRRGG | | Modification type: | Fragment
Monomeric
| | PDB: | | | Structural/functional type: | Function arises from the disordered state
| | Functional classes: | Molecular assembly
| | Functional subclasses: | Protein-DNA binding
| Detection methods:
- Nuclear magnetic resonance (NMR) (pH: 6.5; 2H2O; sodium pyrophosphate 40 mM; ZnSO4 50 mM)
- Nuclear magnetic resonance (NMR) (pH: 6.5; H2O/2H2O (85/15%); sodium pyrophosphate 40 mM; ZnSO4 50 mM)
| References:
- Schwabe JW, Chapman L, Finch JT, Rhodes D, Neuhaus D. "DNA recognition by the oestrogen receptor: from solution to the crystal." Structure. 1993; 1(3): 187-204. PubMed: 16100953
| Comments:
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| References |
- Krust A, Green S, Argos P, Kumar V, Walter P, Bornert JM, Chambon P. "The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors." Embo J. 1986; 5(5): 891-7. PubMed: 3755102
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| Comments |
AV (6-29-2010) PubMed: 3755102
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| If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
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