| General information | | DisProt: | DP00082 | | Name: | Eukaryotic initiation factor 4F subunit p150 | | Synonym(s): | IF4F1_YEAST
eIF-4F p150
eIF4F p150
eIF4G1
mRNA cap-binding protein complex subunit p150
Tif4631p
| | First appeared in release: | Release 2.0 (02/14/2005) | | UniProt: | P39935 | | UniGene: | | | SwissProt: | IF4F1_YEAST | | TrEMBL: | | | NCBI (GI): | 1708417 | | Source organism: | Saccharomyces cerevisiae (Baker's yeast) | | Sequence length: | 952 | | Percent disordered: | 10% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
| | | | | |
MTDETAHPTQ SASKQESAAL KQTGDDQQES QQQRGYTNYN NGSNYTQKKP YNSNRPHQQR - 60
GGKFGPNRYN NRGNYNGGGS FRGGHMGANS SNVPWTGYYN NYPVYYQPQQ MAAAGSAPAN - 120
PIPVEEKSPV PTKIEITTKS GEHLDLKEQH KAKLQSQERS TVSPQPESKL KETSDSTSTS - 180
TPTPTPSTND SKASSEENIS EAEKTRRNFI EQVKLRKAAL EKKRKEQLEG SSGNNNIPMK - 240
TTPENVEEKG SDKPEVTEKT KPAEEKSAEP EVKQETPAEE GEQGEKGQIK EESTPKVLTF - 300
AERLKLKKQQ KEREEKTEGK ENKEVPVQEE TKSAIESAPV PPSEQVKEET EVAETEQSNI - 360
DESATTPAIP TKSDEAEAEV EAEAGDAGTK IGLEAEIETT TDETDDGTNT VSHILNVLKD - 420
ATPIEDVFSF NYPEGIEGPD IKYKKEHVKY TYGPTFLLQF KDKLNVKADA EWVQSTASKI - 480
VIPPGMGRGN RSRDSGRFGN NSSRGHDFRN TSVRNMDDRA NSRTSSKRRS KRMNDDRRSN - 540
RSYTSRRDRE RGSYRNEEKR EDDKPKEEVA PLVPSANRWV PKFKSKKTEK KLAPDGKTEL - 600
LDKDEVERKM KSLLNKLTLE MFDAISSEIL AIANISVWET NGETLKAVIE QIFLKACDEP - 660
HWSSMYAQLC GKVVKELNPD ITDETNEGKT GPKLVLHYLV ARCHAEFDKG WTDKLPTNED - 720
GTPLEPEMMS EEYYAAASAK RRGLGLVRFI GFLYRLNLLT GKMMFECFRR LMKDLTDSPS - 780
EETLESVVEL LNTVGEQFET DSFRTGQATL EGSQLLDSLF GILDNIIQTA KISSRIKFKL - 840
IDIKELRHDK NWNSDKKDNG PKTIQQIHEE EERQRQLKNN SRSNSRRTNN SSNRHSFRRD - 900
APPASKDSFI TTRTYSQRNS QRAPPPKEEP AAPTSTATNM FSALMGESDD EE
|
| Functional narrative |
A member of the EIF4G family. This protein is associated with the mRNA cap structure that is required for ribosomal binding to the mRNA during protein biosynthesis.
|
| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
|
| Region 1 | | Type: | Disordered - Extended | | Name: | | | Location: | 393 - 490 | | Length: | 98 | | Region sequence: |
LEAEIETTTDETDDGTNTVSHILNVLKDATPIEDVFSFNYPEGIEGPDIKYKKEHVKYTY
GPTFLLQFKDKLNVKADAEWVQSTASKIVIPPGMGRGN | | Modification type: | Complex
Fragment
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Molecular assembly
| | Functional subclasses: | Protein-protein binding
| Detection methods:
- SDS-PAGE gel, Aberrant mobility on
- Nuclear magnetic resonance (NMR) (299 K; pH: 7.5; )
- Sensitivity to proteolysis
| References:
- Hershey PE, McWhirter SM, Gross JD, Wagner G, Alber T, Sachs AB. "The Cap-binding protein eIF4E promotes folding of a functional domain of yeast translation initiation factor eIF4G1." J Biol Chem. 1999; 274(30): 21297-304. PubMed: 10409688
| Comments:
|
| Comments |
Additional UniProt IDs: B3LI68 (Strain RM11-1a) and C7GQ70 (Strain JAY291)
|
| If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
Disprot-footer
|
