DP00096: Lipoate-protein ligase A subunit 1FASTA viewXML view

General information
DisProt:DP00096
Name:Lipoate-protein ligase A subunit 1
Synonym(s):Lipoate-protein ligase subunit 1
LPL
EC=2.7.7.63
First appeared in release:Release 3.1 (03/31/2006)
UniProt:Q9HKT1
UniGene: 
SwissProt: LPLA_THEAC
TrEMBL:  
NCBI (GI): 13878582
Source organism:Thermoplasma acidophilum
Sequence length:262
Percent disordered:6%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MEGRLLLLET PGNTRMSLAY DEAIYRSFQY GDKPILRFYR HDRSVIIGYF QVAEEEVDLD - 60
YMKKNGIMLA RRYTGGGAVY HDLGDLNFSV VRSSDDMDIT SMFRTMNEAV VNSLRILGLD - 120
ARPGELNDVS IPVNKKTDIM AGEKKIMGAA GAMRKGAKLW HAAMLVHTDL DMLSAVLKVP - 180
DEKFRDKIAK STRERVANVT DFVDVSIDEV RNALIRGFSE TLHIDFREDT ITEKEESLAR - 240
ELFDKKYSTE EWNMGLLRKE VV

Region 1: 179-193

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:179 - 193
Length:15
Region sequence:

VPDEKFRDKIAKSTR

Modification type: Fragment
PDB: 2ARU:A, 2C8M:A, 2C8M:B, 2C8M:C, 2C8M:D
Structural/functional type:  
Functional classes: Molecular assembly
Functional subclasses: Substrate/ligand binding
Detection methods:
  1. X-ray crystallography (magnesium acetate 0.2 M; PEG 8000 20 %; sodium cacodylate (buffer pH 6.5) 0.1 M)

  2. Sensitivity to proteolysis (273 K; pH: 7.5; DTT 1 mM; NaCl 150 mM; trypsin (w/w) 4 %)
References:
  1. McManus E, Luisi BF, Perham RN. "Structure of a putative lipoate protein ligase from Thermoplasma acidophilum and the mechanism of target selection for post-translational modification." J Mol Biol. 2006; 356(3): 625-37. PubMed: 16384580
Comments:
 


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