DP00101: Gag polyproteinFASTA viewXML view

General information
DisProt:DP00101
Name:Gag polyprotein
Synonym(s):GAG_HV1N5
Pr55Gag
Matrix protein p17 [cleavage product 1]
MA
Capsid protein p24 [cleavage product 2]
CA
Spacer peptide p2 [cleavage product 3]
Nucleocapsid protein p7 [cleavage product 4]
NC
Spacer peptide p1 [cleavage product 5]
p6-gag [cleavage product 6]
First appeared in release:Release 5.4 (10/14/2010)
UniProt:P12493
UniGene: 
SwissProt: GAG_HV1N5
TrEMBL:  
NCBI (GI): 120839
Source organism:Human immunodeficiency virus type 1 (isolate NY5 group M subtype B)(HIV-1)
Sequence length:500
Percent disordered:-1%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MGARASVLSG GELDKWEKIR LRPGGKKQYK LKHIVWASRE LERFAVNPGL LETSEGCRQI - 60
LGQLQPSLQT GSEELRSLYN TIAVLYCVHQ RIDVKDTKEA LDKIEEEQNK SKKKAQQAAA - 120
DTGNNSQVSQ NYPIVQNLQG QMVHQAISPR TLNAWVKVVE EKAFSPEVIP MFSALSEGAT - 180
PQDLNTMLNT VGGHQAAMQM LKETINEEAA EWDRLHPVHA GPIAPGQMRE PRGSDIAGTT - 240
STLQEQIGWM THNPPIPVGE IYKRWIILGL NKIVRMYSPT SILDIRQGPK EPFRDYVDRF - 300
YKTLRAEQAS QEVKNWMTET LLVQNANPDC KTILKALGPG ATLEEMMTAC QGVGGPGHKA - 360
RVLAEAMSQV TNPATIMIQK GNFRNQRKTV KCFNCGKEGH IAKNCRAPRK KGCWKCGKEG - 420
HQMKDCTERQ ANFLGKIWPS HKGRPGNFLQ SRPEPTAPPE ESFRFGEETT TPSQKQEPID - 480
KELYPLASLR SLFGSDPSSQ



Functional narrative    

Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1.



Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Comments


Previous entry DP00101 has been split into polyprotein (DP00101) and cleavage product DP00101_C006. Disorder is characterized on the cleavage product.


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