Annotation for this protein is in progress - please check future releases for more complete information



DP00124: Secretogranin-1FASTA viewXML view

General information
DisProt:DP00124
Name:Secretogranin-1
Synonym(s):SCG1_BOVIN
Secretogranin I
SgI
Chromogranin-B
CgB
Secretogranin-1(476-566) [cleavage product 1]
Peptide BAM-1745 [cleavage product 2]
Secretolytin [cleavage product 3]
First appeared in release:Release 1.0 (08/01/2003)
UniProt:P23389
UniGene:Bt.5448
SwissProt: SCG1_BOVIN
TrEMBL:  
NCBI (GI): 12644006
Source organism:Bos taurus (Bovine)
Sequence length:646
Percent disordered:100%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MQPAALLGLL GATVVAAVSS MPVDIRNHNE EVVTHCIIEV LSNALLKSSA PPITPECRQV - 60
LKKNGKELKD EEKSENENTR FEVRLLRDPA DTSEAPGLSS REDSGEGDAQ VPTVADTESG - 120
GHSRERAGEP PGSQVAKEAK TRYSKSEGQN REEEMVKYQK RERGEVGSEE RLSEGPGKAQ - 180
MAFLNQRNQT PAKKEELVSR YDTQSARGLE KSHSRERSSQ ESGEETKSQE NWPQELQRHP - 240
EGQEAPGESE EDASPEVDKR RSRPRHHHGR SRPDRSSQEG NPPLEEESHV GTGNSDEEKA - 300
RHPAHFRALE EGAEYGEEVR RHSAAQAPGD LQGARFGGRG RGEHQALRRP SEESLEQENK - 360
RHGLSPDLNM AQGYSEESEE ERGPARGPSY RARGGEAAAY STLGQTDEKR FLGETHHRVQ - 420
ESQRDKARRR LPGELRNYLD YGEEKGEEAA RGKWQPQGDP RDADENREEA RLRGKQYAPH - 480
HITEKRLGEL LNPFYDPSQW KSSRFERKDP MDDSFLEGEE ENGLTLNEKN FFPEYNYDWW - 540
EKKPFEEDVN WGYEKRNPVP KLDLKRQYDR VAELDQLLHY RKKSAEFPDF YDSEEQVSPQ - 600
HTAENEEEKA GQGVLTEEEE KELENLAAMD LELQKIAEKF SGTRRG



Functional narrative    

Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. The 16 pairs of basic AA distributed throughout its sequence may be used as proteolytic cleavage sites. Secretolytin has antibacterial activity.

Region 1: 1-646

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:1 - 646
Length:646
Region sequence:

MQPAALLGLLGATVVAAVSSMPVDIRNHNEEVVTHCIIEVLSNALLKSSAPPITPECRQV
LKKNGKELKDEEKSENENTRFEVRLLRDPADTSEAPGLSSREDSGEGDAQVPTVADTESG
GHSRERAGEPPGSQVAKEAKTRYSKSEGQNREEEMVKYQKRERGEVGSEERLSEGPGKAQ
MAFLNQRNQTPAKKEELVSRYDTQSARGLEKSHSRERSSQESGEETKSQENWPQELQRHP
EGQEAPGESEEDASPEVDKRRSRPRHHHGRSRPDRSSQEGNPPLEEESHVGTGNSDEEKA
RHPAHFRALEEGAEYGEEVRRHSAAQAPGDLQGARFGGRGRGEHQALRRPSEESLEQENK
RHGLSPDLNMAQGYSEESEEERGPARGPSYRARGGEAAAYSTLGQTDEKRFLGETHHRVQ
ESQRDKARRRLPGELRNYLDYGEEKGEEAARGKWQPQGDPRDADENREEARLRGKQYAPH
HITEKRLGELLNPFYDPSQWKSSRFERKDPMDDSFLEGEEENGLTLNEKNFFPEYNYDWW
EKKPFEEDVNWGYEKRNPVPKLDLKRQYDRVAELDQLLHYRKKSAEFPDFYDSEEQVSPQ
HTAENEEEKAGQGVLTEEEEKELENLAAMDLELQKIAEKFSGTRRG

Modification type:  
PDB:  
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Yoo SH, Kang YK. "Identification of the secretory vesicle membrane binding region of chromogranin B." FEBS Lett. 1997; 406(3): 259-62. PubMed: 9136897

Comments:
 



Comments


There are a number sequence conflicts according to the UniProt entry. So the sequence associated with the disorder-related paper does not match the sequence provided by UniProt.



Disordered residues lie within the residues corresponding to each of the cleavage products, however, the cleavage products are not discussed in the given reference.


If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us.


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