| General information | | DisProt: | DP00141 | | Name: | Zinc finger FYVE domain-containing protein 9 [Isoform 1] | | Synonym(s): | ZFYV9_HUMAN
Mothers against decapentaplegic homolog-interacting protein
Madh-interacting protein
Smad anchor for receptor activation
Receptor activation anchor
hSARA
Novel serine protease
NSP
| | First appeared in release: | Release 3.0 (02/17/2006) | | UniProt: | O95405-1 | | UniGene: | Hs.532345 | | SwissProt: | ZFYV9_HUMAN | | TrEMBL: | | | NCBI (GI): | 15214067 | | Source organism: | Homo sapiens (Human) | | Sequence length: | 1425 | | Percent disordered: | 6% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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MENYFQAEAY NLDKVLDEFE QNEDETVSST LLDTKWNKIL DPPSHRLSFN PTLASVNESA - 60
VSNESQPQLK VFSLAHSAPL TTEEEDHCAN GQDCNLNPEI ATMWIDENAV AEDQLIKRNY - 120
SWDDQCSAVE VGEKKCGNLA CLPDEKNVLV VAVMHNCDKR TLQNDLQDCN NYNSQSLMDA - 180
FSCSLDNENR QTDQFSFSIN ESTEKDMNSE KQMDPLNRPK TEGRSVNHLC PTSSDSLASV - 240
CSPSQLKDDG SIGRDPSMSA ITSLTVDSVI SSQGTDGCPA VKKQENYIPD EDLTGKISSP - 300
RTDLGSPNSF SHMSEGILMK KEPAEESTTE ESLRSGLPLL LKPDMPNGSG RNNDCERCSD - 360
CLVPNEVRAD ENEGYEHEET LGTTEFLNMT EHFSESQDMT NWKLTKLNEM NDSQVNEEKE - 420
KFLQISQPED TNGDSGGQCV GLADAGLDLK GTCISESEEC DFSTVIDTPA ANYLSNGCDS - 480
YGMQDPGVSF VPKTLPSKED SVTEEKEIEE SKSECYSNIY EQRGNEATEG SGLLLNSTGD - 540
LMKKNYLHNF CSQVPSVLGQ SSPKVVASLP SISVPFGGAR PKQPSNLKLQ IPKPLSDHLQ - 600
NDFPANSGNN TKNKNDILGK AKLGENSATN VCSPSLGNIS NVDTNGEHLE SYEAEISTRP - 660
CLALAPDSPD NDLRAGQFGI SARKPFTTLG EVAPVWVPDS QAPNCMKCEA RFTFTKRRHH - 720
CRACGKVFCA SCCSLKCKLL YMDRKEARVC VICHSVLMNA QAWENMMSAS SQSPNPNNPA - 780
EYCSTIPPLQ QAQASGALSS PPPTVMVPVG VLKHPGAEVA QPREQRRVWF ADGILPNGEV - 840
ADAAKLTMNG TSSAGTLAVS HDPVKPVTTS PLPAETDICL FSGSITQVGS PVGSAMNLIP - 900
EDGLPPILIS TGVKGDYAVE EKPSQISVMQ QLEDGGPDPL VFVLNANLLS MVKIVNYVNR - 960
KCWCFTTKGM HAVGQSEIVI LLQCLPDEKC LPKDIFNHFV QLYRDALAGN VVSNLGHSFF - 1020
SQSFLGSKEH GGFLYVTSTY QSLQDLVLPT PPYLFGILIQ KWETPWAKVF PIRLMLRLGA - 1080
EYRLYPCPLF SVRFRKPLFG ETGHTIMNLL ADFRNYQYTL PVVQGLVVDM EVRKTSIKIP - 1140
SNRYNEMMKA MNKSNEHVLA GGACFNEKAD SHLVCVQNDD GNYQTQAISI HNQPRKVTGA - 1200
SFFVFSGALK SSSGYLAKSS IVEDGVMVQI TAENMDSLRQ ALREMKDFTI TCGKADAEEP - 1260
QEHIHIQWVD DDKNVSKGVV SPIDGKSMET ITNVKIFHGS EYKANGKVIR WTEVFFLEND - 1320
DQHNCLSDPA DHSRLTEHVA KAFCLALCPH LKLLKEDGMT KLGLRVTLDS DQVGYQAGSN - 1380
GQPLPSQYMN DLDSALVPVI HGGACQLSEG PVVMELIFYI LENIV
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| Functional narrative |
SARA is an anchoring protein that
specifically binds to Smad2 and 3, transporting them to the
receptor complex and increasing the efficiency of phosphorylation
by the receptors. Involved in recruiting unphosphorylated forms of SMAD2/SMAD3 to the TGF-beta receptor by controlling their subcellular localization and by interacting and colocalizing with the TGF-beta receptor. Phosphorylation of SMAD2/SMAD3 induces dissociation from ZFYVE9 and formation of SMAD2/SMAD4 complexes and nuclear translocation.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | Smad binding domain | | Location: | 765 - 853 | | Length: | 89 | | Region sequence: |
NMMSASSQSPNPNNPAEYCSTIPPLQQAQASGALSSPPPTVMVPVGVLKHPGAEVAQPRE
QRRVWFADGILPNGEVADAAKLTMNGTSS | | Modification type: | Native
| | PDB: | | | Structural/functional type: | Function arises via a disorder to order transition
| | Functional classes: | Molecular assembly
| | Functional subclasses: | Protein-protein binding
| Detection methods:
- Nuclear magnetic resonance (NMR)
| References:
- Chong PA, Ozdamar B, Wrana JL, Forman-Kay JD. "Disorder in a target for the smad2 mad homology 2 domain and its implications for binding and specificity." J Biol Chem. 2004; 279(39): 40707-14. PubMed: 15231848
| Comments:
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| References |
- Wrana JL, Attisano L. "The Smad pathway." Cytokine Growth Factor Rev. 2000; 11(1-2): 5-13. PubMed: 10708948
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| If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
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