DP00148: Gag polyprotein [Isoform Gag polyprotein]FASTA viewXML view

General information
DisProt:DP00148
Name:Gag polyprotein [Isoform Gag polyprotein]
Synonym(s):GAG_HV1B1
Pr55Gag
Matrix protein p17 [cleavage product 1]
MA
Capsid protein p24 [cleavage product 2]
CA
Spacer peptide p2 [cleavage product 3]
Nucleocapsid protein p7 [cleavage product 4]
NC
Spacer peptide p1 [cleavage product 5]
p6-gag [cleavage product 6]
First appeared in release:Release 5.4 (10/14/2010)
UniProt:P03347
UniGene: 
SwissProt: GAG_HV1B1
TrEMBL:  
NCBI (GI): 120827
Source organism:Human immunodeficiency virus type 1 (isolate BH10 group M subtype B)(HIV-1)
Sequence length:512
Percent disordered:-1%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MGARASVLSG GELDRWEKIR LRPGGKKKYK LKHIVWASRE LERFAVNPGL LETSEGCRQI - 60
LGQLQPSLQT GSEELRSLYN TVATLYCVHQ RIEIKDTKEA LDKIEEEQNK SKKKAQQAAA - 120
DTGHSSQVSQ NYPIVQNIQG QMVHQAISPR TLNAWVKVVE EKAFSPEVIP MFSALSEGAT - 180
PQDLNTMLNT VGGHQAAMQM LKETINEEAA EWDRVHPVHA GPIAPGQMRE PRGSDIAGTT - 240
STLQEQIGWM TNNPPIPVGE IYKRWIILGL NKIVRMYSPT SILDIRQGPK EPFRDYVDRF - 300
YKTLRAEQAS QEVKNWMTET LLVQNANPDC KTILKALGPA ATLEEMMTAC QGVGGPGHKA - 360
RVLAEAMSQV TNTATIMMQR GNFRNQRKMV KCFNCGKEGH TARNCRAPRK KGCWKCGKEG - 420
HQMKDCTERQ ANFLGKIWPS YKGRPGNFLQ SRPEPTAPPF LQSRPEPTAP PEESFRSGVE - 480
TTTPPQKQEP IDKELYPLTS LRSLFGNDPS SQ



Functional narrative    

Matrix protein p17 targets Gag and Gag-pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1.



Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Comments


Previous UniProt ID Q9PY17 was permanently deleted and there was no replacement entry for the protein. The entry DP00148 was modified to include full-length Gag polyprotein (not the same as DP00101, which is a different isolate), which includes the disordered region for nucleocapsid protein p7. A cleavage product entry (DP00148_C004) was added.


Previous entry DP00148 has been split into polyprotein (DP00148) and cleavage product DP00148_C004. Disorder is characterized on the cleavage product.


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