General information | DisProt: | DP00151 | Name: | Neurofilament light polypeptide | Synonym(s): | NFL_PIG
NF-L
Neurofilament triplet L protein
68 kDa neurofilament protein
| First appeared in release: | Release 2.0 (02/14/2005) | UniProt: | P02547 | UniGene: | | SwissProt: | NFL_PIG | TrEMBL: | | NCBI (GI): | 143811426 | Source organism: | Sus scrofa (Pig) | Sequence length: | 549 | Percent disordered: | 19% | Homologues: | |
Native sequence |
10 20 30 40 50 60 | | | | | | MSSFYSEPYY STSYKRRYVE TPRVHISSVR SGYSTARSAY SSYSAPVSSS LSVRRSYSSS - 60 SGLMPSLENL DLSQVAAISN DLKSIRTQEK AQLQDLNDRF ASFIERVHEL EQQNKVLEAQ - 120 LLVLRQKHSE PSRFRALYEQ EIRDLRLAAE DATNEKQALQ GEREGLEETL RNLQARYEEE - 180 VLSREDAEGR LMEARKGADE AALARAELEK RIDSLMDEIA FLKKVHEEEI AELQAQIQYA - 240 QISVEMDVSS KPDLSAALKD IRAQYEKLAA KNMQNAEEWF KSRFTVLTES AAKNTDAVRA - 300 AKDEVSESRR LLKAKTLEIE ACRGMNEALE KQLQELEDKQ NADISAMQDT INKLENELRT - 360 TKSEMARYLK EYQDLLNVKM ALDIEIAAYR KLLEGEETRL SFTSVGSLTT GYSQSSQVFG - 420 RSAYGGLQTS SYLMSTRSFP SYYTSHVQEE QIEVEETIEA AKAEEAKDEP PSEGEAEEEG - 480 KEKEEAEAEA EAEEEGAQEE EEAAEKEESE EAKEEEGGEG EQGEETKEAE EEEKKDEGAG - 540 EEQATKKKD
|
Functional narrative |
NF-L is a member of the type IV cytoplasmic intermediate filament protein family. NF-L, along with two additional members of this group, NF-M and NF-H, combine to form neurofilaments which maintain neural function. It is predominately coiled-coil in structure, however the tail domain is disordered.
|
Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
|
Region 1 | Type: | Disordered - Extended | Name: | | Location: | 444 - 549 | Length: | 106 | Region sequence: |
TSHVQEEQIEVEETIEAAKAEEAKDEPPSEGEAEEEGKEKEEAEAEAEAEEEGAQEEEEA AEKEESEEAKEEEGGEGEQGEETKEAEEEEKKDEGAGEEQATKKKD | Modification type: | Native
| PDB: | | Structural/functional type: | Function arises from the disordered state | Functional classes: | Entropic chain
| Functional subclasses: | Entropic bristle
| Detection methods:
- zz IR/FTIR (Duplicate, to be deleted) (277 K; pH: 7.5; )
| References:
- Geisler N, Plessmann U, Weber K. "The complete amino acid sequence of the major mammalian neurofilament protein (NF-L)." FEBS Lett. 1985; 182(2): 475-8. PubMed: 3920075
- Heimburg T, Schuenemann J, Weber K, Geisler N. "Specific recognition of coiled coils by infrared spectroscopy: analysis of the three structural domains of type III intermediate filament proteins." Biochemistry. 1996; 35(5): 1375-82. PubMed: 8634266
| Comments:
|
If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us. |
Disprot-footer
|