Annotation for this protein is in progress - please check future releases for more complete information



DP00168: Pyridoxine-5'-phosphate oxidaseFASTA viewXML view

General information
DisProt:DP00168
Name:Pyridoxine-5'-phosphate oxidase
Synonym(s):PNPO_HUMAN
EC 1.4.3.5
Pyridoxamine-phosphate oxidase
First appeared in release:Release 3.0 (02/17/2006)
UniProt:Q9NVS9
UniGene:Hs.631742
SwissProt: PNPO_HUMAN
TrEMBL:  
NCBI (GI): 37082126
Source organism:Homo sapiens (Human)
Sequence length:261
Percent disordered:18%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MTCWLRGVTA TFGRPAEWPG YLSHLCGRSA AMDLGPMRKS YRGDREAFEE THLTSLDPVK - 60
QFAAWFEEAV QCPDIGEANA MCLATCTRDG KPSARMLLLK GFGKDGFRFF TNFESRKGKE - 120
LDSNPFASLV FYWEPLNRQV RVEGPVKKLP EEEAECYFHS RPKSSQIGAV VSHQSSVIPD - 180
REYLRKKNEE LEQLYQDQEV PKPKSWGGYV LYPQVMEFWQ GQTNRLHDRI VFRRGLPTGD - 240
SPLGPMTHRG EEDWLYERLA P

Region 1: 1-48

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:1 - 48
Length:48
Region sequence:

MTCWLRGVTATFGRPAEWPGYLSHLCGRSAAMDLGPMRKSYRGDREAF

Modification type: Engineered
PDB:  
Structural/functional type: Relationship to function unknown
Functional classes: Modification site
Functional subclasses: Protein-protein binding
Detection methods:
  1. X-ray crystallography (100 K; Beta-mercaptoethanol 2.5 mM; NaCl 250 mM; polyethyleneimine (1.5%); potassium phosphate (pH 7.5) 50 mM; protein 7 mg/ml; Sodium citrate 20 mM)

References:
  1. Musayev FN, Di Salvo ML, Ko TP, Schirch V, Safo MK. "Structure and properties of recombinant human pyridoxine 5'-phosphate oxidase." Protein Sci. 2003; 12(7): 1455-63. PubMed: 12824491

Comments:
 


If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us.


Disprot-footer
Contact us