Annotations for this protein have been verified by the authors of the corresponding papers


DP00189: Protein NefFASTA viewXML view

General information
DisProt:DP00189
Name:Protein Nef
Synonym(s):NEF_HV112
Negative factor
F-protein
3'ORF
C-terminal core protein [cleavage product 1]
First appeared in release:Release 2.0 (02/14/2005)
UniProt:P04324
UniGene: 
SwissProt: NEF_HV112
TrEMBL:  
NCBI (GI): 128018
Source organism:Human immunodeficiency virus type 1 (isolate PCV12 group M subtype B) (HIV-1)
Sequence length:206
Percent disordered:21%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MGGKWSKSSV VGWPAVRERM RRAEPAADGV GAASRDLEKH GAITSSNTAA NNAACAWLEA - 60
QEEEKVGFPV TPQVPLRPMT YKAAVDLSHF LKEKGGLEGL IHSQRRQDIL DLWIYHTQGY - 120
FPDWQNYTPG PGIRYPLTFG WCYKLVPVEP EKLEEANKGE NTSLLHPVSL HGMDDPEREV - 180
LEWRFDSRLA FHHVARELHP EYFKNC

Region 1: 2-16 Region 2: 17-22 Region 3: 23-34 Region 4: 35-41 Region 5: 42-57

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:2 - 16
Length:15
Region sequence:

GGKWSKSSVVGWPAV

Modification type: Fragment
Native
PDB:  
Structural/functional type: Relationship to function unknown
Functional classes: Unknown
Functional subclasses: Unknown
Detection methods:
 
References:
  1. Geyer M, Munte CE, Schorr J, Kellner R, Kalbitzer HR. "Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein." J Mol Biol. 1999; 289(1): 123-38. PubMed: 10339411
Comments:
The experimental protein consisted of residues 2 - 57 of SwissProt entry P04324.


Region 2
Type:Ordered
Name: 
Location:17 - 22
Length:6
Region sequence:

RERMRR

Modification type: Fragment
Native
PDB:  
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Geyer M, Munte CE, Schorr J, Kellner R, Kalbitzer HR. "Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein." J Mol Biol. 1999; 289(1): 123-38. PubMed: 10339411
Comments:
The experimental protein consisted of residues 2 - 57 of SwissProt entry P04324.


Region 3
Type:Disordered
Name: 
Location:23 - 34
Length:12
Region sequence:

AEPAADGVGAAS

Modification type: Fragment
Native
PDB:  
Structural/functional type: Relationship to function unknown
Functional classes: Unknown
Functional subclasses: Unknown
Detection methods:
 
References:
  1. Geyer M, Munte CE, Schorr J, Kellner R, Kalbitzer HR. "Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein." J Mol Biol. 1999; 289(1): 123-38. PubMed: 10339411
Comments:
The experimental protein consisted of residues 2 - 57 of SwissProt entry P04324.


Region 4
Type:Ordered
Name: 
Location:35 - 41
Length:7
Region sequence:

RDLEKHG

Modification type: Fragment
Native
PDB:  
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Geyer M, Munte CE, Schorr J, Kellner R, Kalbitzer HR. "Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein." J Mol Biol. 1999; 289(1): 123-38. PubMed: 10339411
Comments:
The experimental protein consisted of residues 2 - 57 of SwissProt entry P04324.


Region 5
Type:Disordered
Name: 
Location:42 - 57
Length:16
Region sequence:

AITSSNTAANNAACAW

Modification type: Fragment
Native
PDB:  
Structural/functional type: Relationship to function unknown
Functional classes: Unknown
Functional subclasses: Unknown
Detection methods:
 
References:
  1. Geyer M, Munte CE, Schorr J, Kellner R, Kalbitzer HR. "Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein." J Mol Biol. 1999; 289(1): 123-38. PubMed: 10339411
Comments:
The experimental protein consisted of residues 2 - 57 of SwissProt entry P04324.


Comments


The disordered region is not found in the C-terminal core protein.


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