Annotation for this protein is in progress - please check future releases for more complete information


DP00198: Transcriptional activator protein traRFASTA viewXML view

General information
DisProt:DP00198
Name:Transcriptional activator protein traR
Synonym(s):TRAR_RHIRD
TraR
First appeared in release:Release 2.0 (02/14/2005)
UniProt:P33905
UniGene: 
SwissProt: TRAR_RHIRD
TrEMBL:  
NCBI (GI): 6094514
Source organism:Rhizobium radiobacter (Agrobacterium tumefaciens)(Agrobacterium radiobacter)
Sequence length:234
Percent disordered:100%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MQHWLDKLTD LAAIEGDECI LKTGLADIAD HFGFTGYAYL HIQHRHITAV TNYHRQWQST - 60
YFDKKFEALD PVVKRARSRK HIFTWSGEHE RPTLSKDERA FYDHASDFGI RSGITIPIKT - 120
ANGFMSMFTM ASDKPVIDLD REIDAVAAAA TIGQIHARIS FLRTTPTAED AAWLDPKEAT - 180
YLRWIAVGKT MEEIADVEGV KYNSVRVKLR EAMKRFDVRS KAHLTALAIR RKLI



Functional narrative    

Transcriptional activator protein traR requires Agrobacterium autoinducer (AAI) as it is synthesized for proper folding. Transcriptional activator protein traR synthesized in the absence of AAI is highly sensitive to proteolysis.

Region 1: 1-234

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:1 - 234
Length:234
Region sequence:

MQHWLDKLTDLAAIEGDECILKTGLADIADHFGFTGYAYLHIQHRHITAVTNYHRQWQST
YFDKKFEALDPVVKRARSRKHIFTWSGEHERPTLSKDERAFYDHASDFGIRSGITIPIKT
ANGFMSMFTMASDKPVIDLDREIDAVAAAATIGQIHARISFLRTTPTAEDAAWLDPKEAT
YLRWIAVGKTMEEIADVEGVKYNSVRVKLREAMKRFDVRSKAHLTALAIRRKLI

Modification type: Native
PDB:  
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Molecular recognition effectors
Functional subclasses: Transactivation (transcriptional activation)
Substrate/ligand binding
Detection methods:
  1. Sensitivity to proteolysis
References:
  1. Zhu J, Winans SC. "The quorum-sensing transcriptional regulator TraR requires its cognate signaling ligand for protein folding, protease resistance, and dimerization." Proc Natl Acad Sci U S A. 2001; 98(4): 1507-12. PubMed: 11171981
Comments:
 


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