Annotation for this protein is in progress - please check future releases for more complete information


DP00215: Wiskott-Aldrich syndrome proteinFASTA viewXML view

General information
DisProt:DP00215
Name:Wiskott-Aldrich syndrome protein
Synonym(s):WASP_HUMAN
WASp
First appeared in release:Release 2.1 (03/14/2005)
UniProt:P42768
UniGene:Hs.2157
SwissProt: WASP_HUMAN
TrEMBL:  
NCBI (GI): 1722836
Source organism:Homo sapiens (Human)
Sequence length:501
Percent disordered:7%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
SGGPMGGRPG GRGAPAVQQN IPSTLLQDHE NQRLFEMLGR KCLTLATAVV QLYLALPPGA - 60
EHWTKEHCGA VCFVKDNPQK SYFIRLYGLQ AGRLLWEQEL YSQLVYSTPT PFFHTFAGDD - 120
CQAGLNFADE DEAQAFRALV QEKIQKRNQR QSGDRRQLPP PPTPANEERR GGLPPLPLHP - 180
GGDQGGPPVG PLSLGLATVD IQNPDITSSR YRGLPAPGPS PADKKRSGKK KISKADIGAP - 240
SGFKHVSHVG WDPQNGFDVN NLDPDLRSLF SRAGISEAQL TDAETSKLIY DFIEDQGGLE - 300
AVRQEMRRQE PLPPPPPPSR GGNQLPRPPI VGGNKGRSGP LPPVPLGIAP PPPTPRGPPP - 360
PGRGGPPPPP PPATGRSGPL PPPPPGAGGP PMPPPPPPPP PPPSSGNGPA PPPLPPALVP - 420
AGGLAPGGGR GALLDQIRQG IQLNKTPGAP ESSALQPPPQ SSEGLVGALM HVMQKRSRAI - 480
HSSDEGEDQA GDEDEDDEWD D

Region 1: 230-249 Region 2: 241-249 Region 3: 480-492

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:230 - 249
Length:20
Region sequence:

KKISKADIGAPSGFKHVSHV

Modification type: Engineered
Fragment
Native
PDB:  
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Molecular recognition effectors
Functional subclasses: Protein-protein binding
Detection methods:
 
References:
  1. Kim AS, Kakalis LT, Abdul-Manan N, Liu GA, Rosen MK. "Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein." Nature. 2000; 404(6774): 151-8. PubMed: 10724160
Comments:
Experimental sequence was KKISKADIGAPSGFKHVSHVGWDPQNGFDVNNLDPDLRSLFSRAGISEAQLTDAETSKLI YDFIEDQGGLEAVRQEMRRQ.


Region 2
Type:Disordered
Name: 
Location:241 - 249
Length:9
Region sequence:

SGFKHVSHV

Modification type: Engineered
Fragment
Mutant
PDB:  
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Molecular recognition effectors
Functional subclasses: Protein-protein binding
Detection methods:
 
References:
  1. Kim AS, Kakalis LT, Abdul-Manan N, Liu GA, Rosen MK. "Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein." Nature. 2000; 404(6774): 151-8. PubMed: 10724160
Comments:
Experimental sequence was a fusion of two fragments of WASp joined by a short GS linker. The experimental sequence was K KISKADIGAP SGFKHVSHVG WDPQNGFDVN NLDPDLRSLF SRAGISEAQL TDAETSKLIY DFIEDQGGLE AVRQEMRRQE ggsggs SSEGLVGALM HVMQKRSRAI HSSDEGEDQA GD.


Region 3
Type:Disordered
Name: 
Location:480 - 492
Length:13
Region sequence:

IHSSDEGEDQAGD

Modification type: Engineered
Fragment
Mutant
PDB:  
Structural/functional type: Relationship to function unknown
Functional classes: Unknown
Functional subclasses: Unknown
Detection methods:
 
References:
  1. Kim AS, Kakalis LT, Abdul-Manan N, Liu GA, Rosen MK. "Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein." Nature. 2000; 404(6774): 151-8. PubMed: 10724160
Comments:
Experimental sequence was a fusion of two fragments of WASp joined by a short GS linker. The experimental sequence was K KISKADIGAP SGFKHVSHVG WDPQNGFDVN NLDPDLRSLF SRAGISEAQL TDAETSKLIY DFIEDQGGLE AVRQEMRRQE ggsggs SSEGLVGALM HVMQKRSRAI HSSDEGEDQA GD.



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