Annotations for this protein have been verified by the authors of the corresponding papers



DP00218: Protein phosphatase 1 regulatory subunit 12A [Isoform 2]FASTA viewXML view

General information
DisProt:DP00218
Name:Protein phosphatase 1 regulatory subunit 12A [Isoform 2]
Synonym(s):MYPT1_CHICK
Myosin phosphatase-targeting subunit 1
Myosin phosphatase target subunit 1
Protein phosphatase myosin-binding subunit
PP1M subunit M110
130 kDa myosin-binding subunit of smooth muscle myosin phophatase
M130
First appeared in release:Release 2.1 (03/14/2005)
UniProt:Q90623-2
UniGene:Gga.3159
SwissProt: MYPT1_CHICK
TrEMBL:  
NCBI (GI): 82216979
Source organism:Gallus gallus (Chicken)
Sequence length:963
Percent disordered:31%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MKMADAKQKR NEQLKRWIGS ETDLEPPVVK RKKTKVKFDD GAVFLAACSS GDTEEVLRLL - 60
ERGADINYAN VDGLTALHQA CIDDNVDMVK FLVENGANIN QPDNEGWIPL HAAASCGYLD - 120
IAEYLISQGA HVGAVNSEGD TPLDIAEEEA MEELLQNEVN RQGVDIEAAR KEEERIMLRD - 180
ARQWLNSGHI NDVRHAKSGG TALHVAAAKG YTEVLKLLIQ ARYDVNIKDY DGWTPLHAAA - 240
HWGKEEACRI LVENLCDMEA VNKVGQTAFD VADEDILGYL EELQKKQNLL HSEKREKKSP - 300
LIESTANLDN NQTQKTFKNK ETLIMEQEKN ASSIESLEHE KADEEEEGKK DESSCSSEEE - 360
EDDDSESEAE TDKAKTLANA NTTSTQSASM TAPSVAGGQG TPTSPLKKFP TSTTKVSPKE - 420
EERKDESPAS WRLGLRKTGS YGALAEITAS KEAQKEKDSA GVIRSASSPR LSSSLDNKEK - 480
EKDGKGTRLA YVAPTIPRRL ASTSDIDEKE NSGSFGRRQD DLVSSNVPST ASTVTSSAGL - 540
QKTLPASANT TTKSTTGSTS AGVQSSTSNR LWAEDSTEKE KDSVPTAVTV PVAPSVVNAA - 600
ATTTAMTTAT SGTVSSTSEV RERRRSYLTP VRDEESESQR KARSRQARQS RRSTQGVTLT - 660
DLQEAEKTIG RSRSTRTREQ ENEEKEKEEK EKQDKEKQEE KKESETKDDD YRQRYSRTVE - 720
EPYHRYRPTS TSTSTSSTSS LSTSTSSLSS SSQLNRPNSL IGITSAYSRS GTKESEREGG - 780
KKEEEKEEDK SQPKSIRERR RPREKRRSTG VSFWTQDSDE NEQEHQSDSE EGTNKKETQS - 840
DSLSRYDTGS LSVSSGDRYD SAQGRSGSQS YLEDRKPYCS RLEKEDSTDF KKLYEQILAE - 900
NEKLKAQLHD TNMELTDLKL QLEKTTQRQE RFADRSLLEM EKRVSGKSQY LLGGKKSSRK - 960
KDI

Region 1: 1-299

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:1 - 299
Length:299
Region sequence:

MKMADAKQKRNEQLKRWIGSETDLEPPVVKRKKTKVKFDDGAVFLAACSSGDTEEVLRLL
ERGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLD
IAEYLISQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRD
ARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQARYDVNIKDYDGWTPLHAAA
HWGKEEACRILVENLCDMEAVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKREKKS

Modification type: Fragment
Native
PDB: 1S70:B
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Molecular recognition effectors
Functional subclasses: Protein-protein binding
Detection methods:
 
References:
  1. Terrak M, Kerff F, Langsetmo K, Tao T, Dominguez R. "Structural basis of protein phosphatase 1 regulation." Nature. 2004; 429(6993): 780-4. PubMed: 15164081

Comments:
 


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