Annotation for this protein is in progress - please check future releases for more complete information



DP00219: Protein phosphatase 1 regulatory subunit 11FASTA viewXML view

General information
DisProt:DP00219
Name:Protein phosphatase 1 regulatory subunit 11
Synonym(s):PP1RB_HUMAN
Protein phosphatase inhibitor 3
Hemochromatosis candidate protein V
HCG V
HCG-V
First appeared in release:Release 2.0 (02/14/2005)
UniProt:O60927
UniGene:Hs.82887
SwissProt: PP1RB_HUMAN
TrEMBL:  
NCBI (GI): 74739598
Source organism:Homo sapiens (Human)
Sequence length:126
Percent disordered:100%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MAEAGAGLSE TVTETTVTVT TEPENRSLTI KLRKRKPEKK VEWTSDTVDN EHMGRRSSKC - 60
CCIYEKPRAF GESSTESDEE EEEGCGHTHC VRGHRKGRRR ATLGPTPTTP PQPPDPSQPP - 120
PGPMQH

Region 1: 1-126

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:1 - 126
Length:126
Region sequence:

MAEAGAGLSETVTETTVTVTTEPENRSLTIKLRKRKPEKKVEWTSDTVDNEHMGRRSSKC
CCIYEKPRAFGESSTESDEEEEEGCGHTHCVRGHRKGRRRATLGPTPTTPPQPPDPSQPP
PGPMQH

Modification type: Native
PDB:  
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Molecular recognition effectors
Functional subclasses: Protein-protein binding
Detection methods:
  1. Stability at thermal extremes

  2. SDS-PAGE gel, Aberrant mobility on

  3. Size exclusion/gel filtration chromatography

References:
  1. Zhang J, Zhang L, Zhao S, Lee EY. "Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1." Biochemistry. 1998; 37(47): 16728-34. PubMed: 9843442

Comments:
 


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