Annotation for this protein is in progress - please check future releases for more complete information


DP00223: G2/mitotic-specific cyclin-B1FASTA viewXML view

General information
DisProt:DP00223
Name:G2/mitotic-specific cyclin-B1
Synonym(s):CCNB1_HUMAN
First appeared in release:Release 2.0 (02/14/2005)
UniProt:P14635
UniGene:Hs.23960
SwissProt: CCNB1_HUMAN
TrEMBL:  
NCBI (GI): 116176
Source organism:Homo sapiens (Human)
Sequence length:433
Percent disordered:18%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MALRVTRNSK INAENKAKIN MAGAKRVPTA PAATSKPGLR PRTALGDIGN KVSEQLQAKM - 60
PMKKEAKPSA TGKVIDKKLP KPLEKVPMLV PVPVSEPVPE PEPEPEPEPV KEEKLSPEPI - 120
LVDTASPSPM ETSGCAPAEE DLCQAFSDVI LAVNDVDAED GADPNLCSEY VKDIYAYLRQ - 180
LEEEQAVRPK YLLGREVTGN MRAILIDWLV QVQMKFRLLQ ETMYMTVSII DRFMQNNCVP - 240
KKMLQLVGVT AMFIASKYEE MYPPEIGDFA FVTDNTYTKH QIRQMEMKIL RALNFGLGRP - 300
LPLHFLRRAS KIGEVDVEQH TLAKYLMELT MLDYDMVHFP PSQIAAGAFC LALKILDNGE - 360
WTPTLQHYLS YTEESLLPVM QHLAKNVVMV NQGLTKHMTV KNKYATSKHA KISTLPQLNS - 420
ALVQDLAKAV AKV

Region 1: 1-78

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:ND-cycB
Location:1 - 78
Length:78
Region sequence:

MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKM
PMKKEAKPSATGKVIDKK

Modification type: Fragment
Native
PDB:  
Structural/functional type: Function arises from the disordered state
Functional classes: Molecular recognition effectors
Functional subclasses: Protein-protein binding
Detection methods:
  1. Circular dichroism (CD) spectroscopy, far-UV

  2. Nuclear magnetic resonance (NMR)
References:
  1. Cox CJ, Dutta K, Petri ET, Hwang WC, Lin Y, Pascal SM, Basavappa R. "The regions of securin and cyclin B proteins recognized by the ubiquitination machinery are natively unfolded." FEBS Lett. 2002; 527(1-3): 303-8. PubMed: 12220679
Comments:
 


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