Annotation for this protein is in progress - please check future releases for more complete information



DP00232: Protein phosphatase inhibitor 2FASTA viewXML view

General information
DisProt:DP00232
Name:Protein phosphatase inhibitor 2
Synonym(s):IPP2_RABIT
IPP-2
First appeared in release:Release 3.0 (02/17/2006)
UniProt:P11845
UniGene:Ocu.1811
SwissProt: IPP2_RABIT
TrEMBL:  
NCBI (GI): 1170582
Source organism:Oryctolagus cuniculus (Rabbit)
Sequence length:205
Percent disordered:100%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MAASTASHRP IKGILKNKTS STSSRVASAE QPRGSVDEEL SKKSQKWDEM NILATYHPAD - 60
KDYGLMKIDE PSTPYHSMIG DDDDAYSDTE TTEAMTPDTL AKKLAAAEGS EPKYRIREQE - 120
SSGEEDSDLS PEEREKKRQF EMKRKLHYNE GLNIKLARQL ISKDLHDDEE DEEMSETADG - 180
ESMNTEESNQ GSTPSDQRQN KSQSS

Region 1: 1-205

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:1 - 205
Length:205
Region sequence:

MAASTASHRPIKGILKNKTSSTSSRVASAEQPRGSVDEELSKKSQKWDEMNILATYHPAD
KDYGLMKIDEPSTPYHSMIGDDDDAYSDTETTEAMTPDTLAKKLAAAEGSEPKYRIREQE
SSGEEDSDLSPEEREKKRQFEMKRKLHYNEGLNIKLARQLISKDLHDDEEDEEMSETADG
ESMNTEESNQGSTPSDQRQNKSQSS

Modification type: Monomeric
Native
PDB:  
Structural/functional type: Function arises via a disorder to order transition
Functional classes: Molecular recognition effectors
Functional subclasses: Protein-protein binding
Detection methods:
  1. Analytical ultracentrifugation

  2. Size exclusion/gel filtration chromatography

  3. Stability at thermal extremes

  4. SDS-PAGE gel, Aberrant mobility on

  5. Stability at pH extremes

References:
  1. Foulkes JG, Cohen P. "The regulation of glycogen metabolism. Purification and properties of protein phosphatase inhibitor-2 from rabbit skeletal muscle." Eur J Biochem. 1980; 105(1): 195-203. PubMed: 6245879

  2. Yang J, Hurley TD, DePaoli-Roach AA. "Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif." J Biol Chem. 2000; 275(30): 22635-44. PubMed: 10807923

Comments:
 



References

  1. Park IK, Roach P, Bondor J, Fox SP, DePaoli-Roach AA. "Molecular mechanism of the synergistic phosphorylation of phosphatase inhibitor-2. Cloning, expression, and site-directed mutagenesis of inhibitor-2." J Biol Chem. 1994; 269(2): 944-54. PubMed: 8288648



Comments


Additional UniGene: Ocu.6939


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