Annotation for this protein is in progress - please check future releases for more complete information



DP00233: Fibrinogen alpha chain [Isoform 1 (Alpha-E)]FASTA viewXML view

General information
DisProt:DP00233
Name:Fibrinogen alpha chain [Isoform 1 (Alpha-E)]
Synonym(s):FIBA_CHICK
Fibrinopeptide A [cleavage product 1]
First appeared in release:Release 2.2 (04/14/2005)
UniProt:P14448-1
UniGene:Gga.34280
SwissProt: FIBA_CHICK
TrEMBL:  
NCBI (GI): 1706798
Source organism:Gallus gallus (Chicken)
Sequence length:741
Percent disordered:40%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MIPVTILCVL LCLNLAWAQD GKTTFEKEGG GGRGPRILEN MHESSCKYEK NWPICVDDDW - 60
GTKCPSCCRM QGIIDDTDQN YSQRIDNIRQ QLADSQNKYK TSNRVIVETI NILKPGLEGA - 120
QQLDENYGHV STELRRRIVT LKQRVATQVN RIKALQNSIQ EQVVEMKRLE VDIDIKIRAC - 180
KGSCARSFDY QVDKEGYDNI QKHLTQASSI DMHPDFQTTT LSTLKMRPLK DSNVPEHFKL - 240
KPSPEMQAMS AFNNIKQMQV VLERPETDHV AEARGDSSPS HTGKLITSSH RRESPSLVDK - 300
TSSASSVHRC TRTVTKKVIS GPDGPREEIV EKMVSSDGSD CSHLQGGREG STYHFSGTGD - 360
FHKLDRLLPD LESFFTHDSV STSSRHSIGS STSSHVTGAG SSHLGTGGKD KFTDLGEEEE - 420
DDFGGLQPSG FAAGSASHSK TVLTSSSSSF NKGGSTFETK SLKTRETSEQ LGGVQHDQSA - 480
EDTPDFKARS FRPAAMSTRR SYNGKDCDDI RQKHTSGAKS GIFKIKPEGS NKVLSVYCDQ - 540
ETTLGGWLLI QQRMDGSVNF NRTWQDYRRG FGSVDGKGQG ELWLGNENIH LLTQNDTLLR - 600
VELEDWDGNA AYAEYIVQVG TEAEGYALTV SSYEGTAGDA LVAGWLEEGS EYTSHAQMQF - 660
STFDRDQDHW EESCAEVYGG GWWYNSCQAA NLNGIYYPGG HYDPRYNVPY EIENGVVWIP - 720
FRASDYSLKV VRMKIRPLET L



Functional narrative    

Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.

Region 1: 19-44 Region 2: 237-509

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:19 - 44
Length:26
Region sequence:

QDGKTTFEKEGGGGRGPRILENMHES

Modification type: Fragment
Native
PDB: 1M1J:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
  1. X-ray crystallography

References:
  1. Yang Z, Kollman JM, Pandi L, Doolittle RF. "Crystal structure of native chicken fibrinogen at 2.7 A resolution." Biochemistry. 2001; 40(42): 12515-23. PubMed: 11601975

Comments:
 



Region 2
Type:Disordered
Name: 
Location:237 - 509
Length:273
Region sequence:

HFKLKPSPEMQAMSAFNNIKQMQVVLERPETDHVAEARGDSSPSHTGKLITSSHRRESPS
LVDKTSSASSVHRCTRTVTKKVISGPDGPREEIVEKMVSSDGSDCSHLQGGREGSTYHFS
GTGDFHKLDRLLPDLESFFTHDSVSTSSRHSIGSSTSSHVTGAGSSHLGTGGKDKFTDLG
EEEEDDFGGLQPSGFAAGSASHSKTVLTSSSSSFNKGGSTFETKSLKTRETSEQLGGVQH
DQSAEDTPDFKARSFRPAAMSTRRSYNGKDCDD

Modification type: Fragment
Native
PDB: 1M1J:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
 
References:
  1. Yang Z, Kollman JM, Pandi L, Doolittle RF. "Crystal structure of native chicken fibrinogen at 2.7 A resolution." Biochemistry. 2001; 40(42): 12515-23. PubMed: 11601975

Comments:
 



References

  1. Doolittle RF. "Structural basis of the fibrinogen-fibrin transformation: contributions from X-ray crystallography." Blood Rev. 2003; 17(1): 33-41. PubMed: 12490209



Comments


Disordered residues lie within the region for cleavage product 1, however, there is no experimental evidence that indicates that this product is disordered.


If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us.


Disprot-footer
Contact us