General information | DisProt: | DP00233 | Name: | Fibrinogen alpha chain [Isoform 1 (Alpha-E)] | Synonym(s): | FIBA_CHICK
Fibrinopeptide A [cleavage product 1]
| First appeared in release: | Release 2.2 (04/14/2005) | UniProt: | P14448-1 | UniGene: | Gga.34280 | SwissProt: | FIBA_CHICK | TrEMBL: | | NCBI (GI): | 1706798 | Source organism: | Gallus gallus (Chicken) | Sequence length: | 741 | Percent disordered: | 40% | Homologues: | |
Native sequence |
10 20 30 40 50 60 | | | | | | MIPVTILCVL LCLNLAWAQD GKTTFEKEGG GGRGPRILEN MHESSCKYEK NWPICVDDDW - 60 GTKCPSCCRM QGIIDDTDQN YSQRIDNIRQ QLADSQNKYK TSNRVIVETI NILKPGLEGA - 120 QQLDENYGHV STELRRRIVT LKQRVATQVN RIKALQNSIQ EQVVEMKRLE VDIDIKIRAC - 180 KGSCARSFDY QVDKEGYDNI QKHLTQASSI DMHPDFQTTT LSTLKMRPLK DSNVPEHFKL - 240 KPSPEMQAMS AFNNIKQMQV VLERPETDHV AEARGDSSPS HTGKLITSSH RRESPSLVDK - 300 TSSASSVHRC TRTVTKKVIS GPDGPREEIV EKMVSSDGSD CSHLQGGREG STYHFSGTGD - 360 FHKLDRLLPD LESFFTHDSV STSSRHSIGS STSSHVTGAG SSHLGTGGKD KFTDLGEEEE - 420 DDFGGLQPSG FAAGSASHSK TVLTSSSSSF NKGGSTFETK SLKTRETSEQ LGGVQHDQSA - 480 EDTPDFKARS FRPAAMSTRR SYNGKDCDDI RQKHTSGAKS GIFKIKPEGS NKVLSVYCDQ - 540 ETTLGGWLLI QQRMDGSVNF NRTWQDYRRG FGSVDGKGQG ELWLGNENIH LLTQNDTLLR - 600 VELEDWDGNA AYAEYIVQVG TEAEGYALTV SSYEGTAGDA LVAGWLEEGS EYTSHAQMQF - 660 STFDRDQDHW EESCAEVYGG GWWYNSCQAA NLNGIYYPGG HYDPRYNVPY EIENGVVWIP - 720 FRASDYSLKV VRMKIRPLET L
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Functional narrative |
Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
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Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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Region 1 | Type: | Disordered | Name: | | Location: | 19 - 44 | Length: | 26 | Region sequence: |
QDGKTTFEKEGGGGRGPRILENMHES | Modification type: | Fragment
Native
| PDB: | 1M1J:A | Structural/functional type: | | Functional classes: | | Functional subclasses: | | Detection methods:
- X-ray crystallography
| References:
- Yang Z, Kollman JM, Pandi L, Doolittle RF. "Crystal structure of native chicken fibrinogen at 2.7 A resolution." Biochemistry. 2001; 40(42): 12515-23. PubMed: 11601975
| Comments:
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Region 2 | Type: | Disordered | Name: | | Location: | 237 - 509 | Length: | 273 | Region sequence: |
HFKLKPSPEMQAMSAFNNIKQMQVVLERPETDHVAEARGDSSPSHTGKLITSSHRRESPS LVDKTSSASSVHRCTRTVTKKVISGPDGPREEIVEKMVSSDGSDCSHLQGGREGSTYHFS GTGDFHKLDRLLPDLESFFTHDSVSTSSRHSIGSSTSSHVTGAGSSHLGTGGKDKFTDLG EEEEDDFGGLQPSGFAAGSASHSKTVLTSSSSSFNKGGSTFETKSLKTRETSEQLGGVQH DQSAEDTPDFKARSFRPAAMSTRRSYNGKDCDD | Modification type: | Fragment
Native
| PDB: | 1M1J:A | Structural/functional type: | | Functional classes: | | Functional subclasses: | | Detection methods: | References:
- Yang Z, Kollman JM, Pandi L, Doolittle RF. "Crystal structure of native chicken fibrinogen at 2.7 A resolution." Biochemistry. 2001; 40(42): 12515-23. PubMed: 11601975
| Comments:
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References |
- Doolittle RF. "Structural basis of the fibrinogen-fibrin transformation: contributions from X-ray crystallography." Blood Rev. 2003; 17(1): 33-41. PubMed: 12490209
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Comments |
Disordered residues lie within the region for cleavage product 1, however, there is no experimental evidence that indicates that this product is disordered.
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