| General information | | DisProt: | DP00234 | | Name: | Fibrinogen beta chain | | Synonym(s): | FIBB_CHICK
Fibrinopeptide B [cleavage product 1]
| | First appeared in release: | Release 2.2 (04/14/2005) | | UniProt: | Q02020 | | UniGene: | Gga.41812 | | SwissProt: | FIBB_CHICK | | TrEMBL: | | | NCBI (GI): | 399491 | | Source organism: | Gallus gallus (Chicken) | | Sequence length: | 463 | | Percent disordered: | 13% | | Homologues: | |
| Native sequence |
10 20 30 40 50 60
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ASVEYDNEED SPQIDARAHR PLDKRQEAAP TLRPVAPPIS GTGYQPRPPK QDKQAMKKGP - 60
IIYPDAGGCK HPLDELGVLC PTGCELQTTL LKQEKTVKPV LRDLKDRVAK FSDTSTTMYQ - 120
YVNMIDNKLV KTQKQRKDND IILSEYNTEM ELHYNYIKDN LDNNIPSSLR VLRAVIDSLH - 180
KKIQKLENAI ATQTDYCRSP CVASCNIPVV SGRECEDIYR KGGETSEMYI IQPDPFTTPY - 240
RVYCDMETDN GGWTLIQNRQ DGSVNFGRAW DEYKRGFGNI AKSGGKKYCD TPGEYWLGND - 300
KISQLTKIGP TKVLIEMEDW NGDKVSALYG GFTIHNEGNK YQLSVSNYKG NAGNALMEGA - 360
SQLYGENRTM TIHNGMYFST YDRDNDGWLT TDPRKQCSKE DGGGWWYNRC HAANPNGRYY - 420
WGGTYSWDMA KHGTDDGIVW MNWKGSWYSM KKMSMKIKPY FPD
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| Functional narrative |
Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
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| Map of ordered and disordered regions |
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.
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| Region 1 | | Type: | Disordered | | Name: | | | Location: | 1 - 62 | | Length: | 62 | | Region sequence: |
ASVEYDNEEDSPQIDARAHRPLDKRQEAAPTLRPVAPPISGTGYQPRPPKQDKQAMKKGP
II | | Modification type: | Fragment
Native
| | PDB: | 1M1J:B | | Structural/functional type: | | | Functional classes: | | | Functional subclasses: | | Detection methods:
- X-ray crystallography
| References:
- Yang Z, Kollman JM, Pandi L, Doolittle RF. "Crystal structure of native chicken fibrinogen at 2.7 A resolution." Biochemistry. 2001; 40(42): 12515-23. PubMed: 11601975
| Comments:
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| References |
- Doolittle RF. "Structural basis of the fibrinogen-fibrin transformation: contributions from X-ray crystallography." Blood Rev. 2003; 17(1): 33-41. PubMed: 12490209
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| Comments |
Disordered residues lie within the region for cleavage product 1, however, there is no experimental evidence that indicates that this product is disordered.
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