Annotation for this protein is in progress - please check future releases for more complete information


DP00239: Carbon monoxide dehydrogenaseFASTA viewXML view

General information
DisProt:DP00239
Name:Carbon monoxide dehydrogenase
Synonym(s):COOS_RHORU
CODH
EC=1.2.99.2
First appeared in release:Release 3.1 (03/31/2006)
UniProt:P31896
UniGene: 
SwissProt: COOS_RHORU
TrEMBL:  
NCBI (GI): 399279
Source organism:Rhodospirillum rubrum
Sequence length:639
Percent disordered:5%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MTHHDCAHCS SDACATEMLN LAEANSIETA WHRYEKQQPQ CGFGSAGLCC RICLKGPCRI - 60
DPFGEGPKYG VCGADRDTIV ARHLVRMIAA GTAAHSEHGR HIALAMQHIS QGELHDYSIR - 120
DEAKLYAIAK TLGVATEGRG LLAIVGDLAA ITLGDFQNQD YDKPCAWLAA SLTPRRVKRL - 180
GDLGLLPHNI DASVAQTMSR THVGCDADPT NLILGGLRVA MADLDGSMLA TELSDALFGT - 240
PQPVVSAANL GVMKRGAVNI AVNGHNPMLS DIICDVAADL RDEAIAAGAA EGINIIGICC - 300
TGHEVMMRHG VPLATNYLSQ ELPILTGALE AMVVDVQCIM PSLPRIAECF HTQIITTDKH - 360
NKISGATHVP FDEHKAVETA KTIIRMAIAA FGRRDPNRVA IPAFKQKSIV GFSAEAVVAA - 420
LAKVNADDPL KPLVDNVVNG NIQGIVLFVG CNTTKVQQDS AYVDLAKSLA KRNVLVLATG - 480
CAAGAFAKAG LMTSEATTQY AGEGLKGVLS AIGTAAGLGG PLPLVMHMGS CVDNSRAVAL - 540
ATALANKLGV DLSDLPLVAS APECMSEKAL AIGSWAVTIG LPTHVGSVPP VIGSQIVTKL - 600
VTETAKDLVG GYFIVDTDPK SAGDKLYAAI QERRAGLGL

Region 1: 1-27 Region 2: 638-639

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:1 - 27
Length:27
Region sequence:

MTHHDCAHCSSDACATEMLNLAEANSI

Modification type: Complex
PDB:  
Structural/functional type: Function arises from the disordered state
Functional classes: Unknown
Functional subclasses: Substrate/ligand binding
Detection methods:
  1. X-ray crystallography ( 2-methyl-2,4-pentanediol (5%); calcium chloride 0.4 M; polyethylene glycol 8000 (10%); Tris buffer (pH 7.5) 0.1 M)
References:
  1. Drennan CL, Heo J, Sintchak MD, Schreiter E, Ludden PW. "Life on carbon monoxide: X-ray structure of Rhodospirillum rubrum Ni-Fe-S carbon monoxide dehydrogenase." Proc Natl Acad Sci U S A. 2001; 98(21): 11973-8. PubMed: 11593006
Comments:
 



Region 2
Type:Disordered
Name: 
Location:638 - 639
Length:2
Region sequence:

GL

Modification type: Complex
PDB:  
Structural/functional type: Function arises from the disordered state
Functional classes: Unknown
Functional subclasses: Substrate/ligand binding
Detection methods:
  1. X-ray crystallography ( 2-methyl-2,4-pentanediol (5%); calcium chloride 0.4 M; polyethylene glycol 8000 (10%); Tris buffer (pH 7.5) 0.1 M)
References:
  1. Drennan CL, Heo J, Sintchak MD, Schreiter E, Ludden PW. "Life on carbon monoxide: X-ray structure of Rhodospirillum rubrum Ni-Fe-S carbon monoxide dehydrogenase." Proc Natl Acad Sci U S A. 2001; 98(21): 11973-8. PubMed: 11593006
Comments:
 



References

  1. Kerby RL, Hong SS, Ensign SA, Coppoc LJ, Ludden PW, Roberts GP. "Genetic and physiological characterization of the Rhodospirillum rubrum carbon monoxide dehydrogenase system." J Bacteriol. 1992; 174(16): 5284-94. PubMed: 1644755



Comments


CODH is organized as a dimer which has two Ni-Fe-S C-clusters, two [Fe4S4] B-clusters, and an [Fe4S4] cluster (bridge between the monomers).


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