Annotation for this protein is in progress - please check future releases for more complete information


DP00240: Alpha-adducin [Isoform 1]FASTA viewXML view

General information
DisProt:DP00240
Name:Alpha-adducin [Isoform 1]
Synonym(s):ADDA_HUMAN
Erythrocyte adducin subunit alpha
First appeared in release:Release 2.2 (04/14/2005)
UniProt:P35611-1
UniGene:Hs.183706
SwissProt: ADDA_HUMAN
TrEMBL:  
NCBI (GI): 12644231
Source organism:Homo sapiens (Human)
Sequence length:737
Percent disordered:42%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MNGDSRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN MMEQKKRVSM - 60
ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTT NVPNVYPAAP QGGMAALNMS - 120
LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA AFYRLADLFG WSQLIYNHIT TRVNSEQEHF - 180
LIVPFGLLYS EVTASSLVKI NLQGDIVDRG STNLGVNQAG FTLHSAIYAA RPDVKCVVHI - 240
HTPAGAAVSA MKCGLLPISP EALSLGEVAY HDYHGILVDE EEKVLIQKNL GPKSKVLILR - 300
NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLNPEKYK AKSRSPGSPV - 360
GEGTGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL REKSKKYSDV EVPASVTGYS - 420
FASDGDSGTC SPLRHSFQKQ QREKTRWLNS GRGDEASEEG QNGSSPKSKT KWTKEDGHRT - 480
STSAVPNLFV PLNTNPKEVQ EMRNKIREQN LQDIKTAGPQ SQVLCGVVMD RSLVQGELVT - 540
ASKAIIEKEY QPHVIVSTTG PNPFTTLTDR ELEEYRREVE RKQKGSEENL DEAREQKEKS - 600
PPDQPAVPHP PPSTPIKLEE DLVPEPTTGD DSDAATFKPT LPDLSPDEPS EALGFPMLEK - 660
EEEAHRPPSP TEAPTEASPE PAPDPAPVAE EAAPSAVEEG AAADPGSDGS PGKSPSKKKK - 720
KFRTPSFLKK SKKKSDS

Region 1: 430-737

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:tail
Location:430 - 737
Length:308
Region sequence:

CSPLRHSFQKQQREKTRWLNSGRGDEASEEGQNGSSPKSKTKWTKEDGHRTSTSAVPNLF
VPLNTNPKEVQEMRNKIREQNLQDIKTAGPQSQVLCGVVMDRSLVQGELVTASKAIIEKE
YQPHVIVSTTGPNPFTTLTDRELEEYRREVERKQKGSEENLDEAREQKEKSPPDQPAVPH
PPPSTPIKLEEDLVPEPTTGDDSDAATFKPTLPDLSPDEPSEALGFPMLEKEEEAHRPPS
PTEAPTEASPEPAPDPAPVAEEAAPSAVEEGAAADPGSDGSPGKSPSKKKKKFRTPSFLK
KSKKKSDS

Modification type: Fragment
Monomeric
Native
PDB:  
Structural/functional type: Relationship to function unknown
Functional classes: Molecular assembly
Functional subclasses: Protein-protein binding
Detection methods:
  1. Circular dichroism (CD) spectroscopy, far-UV

  2. SDS-PAGE gel, Aberrant mobility on

  3. Sensitivity to proteolysis
References:
  1. Hughes CA, Bennett V. "Adducin: a physical model with implications for function in assembly of spectrin-actin complexes." J Biol Chem. 1995; 270(32): 18990-6. PubMed: 7642559
Comments:
 


If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us.


Disprot-footer
Contact us