Annotation for this protein is in progress - please check future releases for more complete information


DP00241: Beta-adducin [Isoform 1]FASTA viewXML view

General information
DisProt:DP00241
Name:Beta-adducin [Isoform 1]
Synonym(s):ADDB_HUMAN
Erythrocyte adducin subunit beta
First appeared in release:Release 2.2 (04/14/2005)
UniProt:P35612-1
UniGene:Hs.188528
SwissProt: ADDB_HUMAN
TrEMBL:  
NCBI (GI): 543774
Source organism:Homo sapiens (Human)
Sequence length:726
Percent disordered:44%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MSEETVPEAA SPPPPQGQPY FDRFSEDDPE YMRLRNRAAD LRQDFNLMEQ KKRVTMILQS - 60
PSFREELEGL IQEQMKKGNN SSNIWALRQI ADFMASTSHA VFPTSSMNVS MMTPINDLHT - 120
ADSLNLAKGE RLMRCKISSV YRLLDLYGWA QLSDTYVTLR VSKEQDHFLI SPKGVSCSEV - 180
TASSLIKVNI LGEVVEKGSS CFPVDTTGFC LHSAIYAARP DVRCIIHLHT PATAAVSAMK - 240
WGLLPVSHNA LLVGDMAYYD FNGEMEQEAD RINLQKCLGP TCKILVLRNH GVVALGDTVE - 300
EAFYKIFHLQ AACEIQVSAL SSAGGVENLI LLEQEKHRPH EVGSVQWAGS TFGPMQKSRL - 360
GEHEFEALMR MLDNLGYRTG YTYRHPFVQE KTKHKSEVEI PATVTAFVFE EDGAPVPALR - 420
QHAQKQQKEK TRWLNTPNTY LRVNVADEVQ RSMGSPRPKT TWMKADEVEK SSSGMPIRIE - 480
NPNQFVPLYT DPQEVLEMRN KIREQNRQDV KSAGPQSQLL ASVIAEKSRS PSTESQLMSK - 540
GDEDTKDDSE ETVPNPFSQL TDQELEEYKK EVERKKLELD GEKETAPEEP GSPAKSAPAS - 600
PVQSPAKEAE TKSPLVSPSK SLEEGTKKTE TSKAATTEPE TTQPEGVVVN GREEEQTAEE - 660
ILSKGLSQMT TSADTDVDTS KDKTESVTSG PMSPEGSPSK SPSKKKKKFR TPSFLKKSKK - 720
KEKVES

Region 1: 409-726

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:tail
Location:409 - 726
Length:318
Region sequence:

FEEDGAPVPALRQHAQKQQKEKTRWLNTPNTYLRVNVADEVQRSMGSPRPKTTWMKADEV
EKSSSGMPIRIENPNQFVPLYTDPQEVLEMRNKIREQNRQDVKSAGPQSQLLASVIAEKS
RSPSTESQLMSKGDEDTKDDSEETVPNPFSQLTDQELEEYKKEVERKKLELDGEKETAPE
EPGSPAKSAPASPVQSPAKEAETKSPLVSPSKSLEEGTKKTETSKAATTEPETTQPEGVV
VNGREEEQTAEEILSKGLSQMTTSADTDVDTSKDKTESVTSGPMSPEGSPSKSPSKKKKK
FRTPSFLKKSKKKEKVES

Modification type: Fragment
Monomeric
Native
PDB:  
Structural/functional type: Relationship to function unknown
Functional classes: Molecular assembly
Functional subclasses: Protein-protein binding
Detection methods:
  1. Circular dichroism (CD) spectroscopy, far-UV

  2. SDS-PAGE gel, Aberrant mobility on

  3. Sensitivity to proteolysis
References:
  1. Hughes CA, Bennett V. "Adducin: a physical model with implications for function in assembly of spectrin-actin complexes." J Biol Chem. 1995; 270(32): 18990-6. PubMed: 7642559
Comments:
 


If you have any comments or wish to provide additional references to this protein or its disordered region(s), please click here to e-mail us.


Disprot-footer
Contact us