Annotation for this protein is in progress - please check future releases for more complete information


DP00243: DNA-repair protein complementing XP-A cellsFASTA viewXML view

General information
DisProt:DP00243
Name:DNA-repair protein complementing XP-A cells
Synonym(s):Xeroderma pigmentosum group A complementing protein [H. sapiens]
XPA
XPA_HUMAN
First appeared in release:Release 3.0 (02/17/2006)
UniProt:P23025
UniGene: 
SwissProt: XPA_HUMAN
TrEMBL:  
NCBI (GI):  
Source organism:Homo sapiens (Human)
Sequence length:273
Percent disordered:10%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MAAADGALPE AAALEQPAEL PASVRASIER KRQRALMLRQ ARLAARPYSA TAAAATGGMA - 60
NVKAAPKIID TGGGFILEEE EEEEQKIGKV VHQPGPVMEF DYVICEECGK EFMDSYLMNH - 120
FDLPTCDNCR DADDKHKLIT KTEAKQEYLL KDCDLEKREP PLKFIVKKNP HHSQWGDMKL - 180
YLKLQIVKRS LEVWGSQEAL EEAKEVRQEN REKMKQKKFD KKVKELRRAV RSSVWKRETI - 240
VHQHEYGPEE NLEDDMYRKT CTMCGHELTY EKM

Region 4: 10-157 Region 1: 158-158 Region 5: 159-167 Region 2: 168-179 Region 6: 180-205 Region 3: 206-219

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:158 - 158
Length:1
Region sequence:

R

Modification type: Fragment
PDB: 1XPA:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
  1. Nuclear magnetic resonance (NMR) (303 K; pH: 6.5; )
References:
  1. Ikegami T, Kuraoka I, Saijo M, Kodo N, Kyogoku Y, Morikawa K, Tanaka K, Shirakawa M. "Solution structure of the DNA- and RPA-binding domain of the human repair factor XPA." Nat Struct Biol. 1998; 5(8): 701-706. PubMed: 9699634

  2. Ikegami T, Kuraoka I, Saijo M, Kodo N, Kyogoku Y, Morikawa K, Tanaka K, Shirakawa M. "Resonance assignments, solution structure, and backbone dynamics of the DNA- and RPA-binding domain of human repair factor XPA." J Biochem (Tokyo). 1999; 125(3): 495-506. PubMed: 10050037
Comments:
 



Region 2
Type:Disordered
Name: 
Location:168 - 179
Length:12
Region sequence:

KNPHHSQWGDMK

Modification type: Fragment
PDB: 1XPA:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
  1. Nuclear magnetic resonance (NMR) (303 K; pH: 6.5; )
References:
  1. Ikegami T, Kuraoka I, Saijo M, Kodo N, Kyogoku Y, Morikawa K, Tanaka K, Shirakawa M. "Solution structure of the DNA- and RPA-binding domain of the human repair factor XPA." Nat Struct Biol. 1998; 5(8): 701-706. PubMed: 9699634

  2. Ikegami T, Kuraoka I, Saijo M, Kodo N, Kyogoku Y, Morikawa K, Tanaka K, Shirakawa M. "Resonance assignments, solution structure, and backbone dynamics of the DNA- and RPA-binding domain of human repair factor XPA." J Biochem (Tokyo). 1999; 125(3): 495-506. PubMed: 10050037
Comments:
 



Region 3
Type:Disordered
Name: 
Location:206 - 219
Length:14
Region sequence:

VRQENREKMKQKKF

Modification type: Fragment
PDB: 1XPA:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
  1. Nuclear magnetic resonance (NMR) (303 K; pH: 6.5; )
References:
  1. Ikegami T, Kuraoka I, Saijo M, Kodo N, Kyogoku Y, Morikawa K, Tanaka K, Shirakawa M. "Solution structure of the DNA- and RPA-binding domain of the human repair factor XPA." Nat Struct Biol. 1998; 5(8): 701-706. PubMed: 9699634

  2. Ikegami T, Kuraoka I, Saijo M, Kodo N, Kyogoku Y, Morikawa K, Tanaka K, Shirakawa M. "Resonance assignments, solution structure, and backbone dynamics of the DNA- and RPA-binding domain of human repair factor XPA." J Biochem (Tokyo). 1999; 125(3): 495-506. PubMed: 10050037
Comments:
 



Region 4
Type:Ordered
Name: 
Location:10 - 157
Length:148
Region sequence:

EAAALEQPAELPASVRASIERKRQRALMLRQARLAARPYSATAAAATGGMANVKAAPKII
DTGGGFILEEEEEEEQKIGKVVHQPGPVMEFDYVICEECGKEFMDSYLMNHFDLPTCDNC
RDADDKHKLITKTEAKQEYLLKDCDLEK

Modification type:  
PDB: 1XPA:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
  1. Nuclear magnetic resonance (NMR) (303 K; pH: 6.5; )
References:
  1. Ikegami T, Kuraoka I, Saijo M, Kodo N, Kyogoku Y, Morikawa K, Tanaka K, Shirakawa M. "Solution structure of the DNA- and RPA-binding domain of the human repair factor XPA." Nat Struct Biol. 1998; 5(8): 701-706. PubMed: 9699634

  2. Ikegami T, Kuraoka I, Saijo M, Kodo N, Kyogoku Y, Morikawa K, Tanaka K, Shirakawa M. "Resonance assignments, solution structure, and backbone dynamics of the DNA- and RPA-binding domain of human repair factor XPA." J Biochem (Tokyo). 1999; 125(3): 495-506. PubMed: 10050037
Comments:
 



Region 5
Type:Ordered
Name: 
Location:159 - 167
Length:9
Region sequence:

EPPLKFIVK

Modification type:  
PDB: 1XPA:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
  1. Nuclear magnetic resonance (NMR) (303 K; pH: 6.5; )
References:
  1. Ikegami T, Kuraoka I, Saijo M, Kodo N, Kyogoku Y, Morikawa K, Tanaka K, Shirakawa M. "Solution structure of the DNA- and RPA-binding domain of the human repair factor XPA." Nat Struct Biol. 1998; 5(8): 701-706. PubMed: 9699634

  2. Ikegami T, Kuraoka I, Saijo M, Kodo N, Kyogoku Y, Morikawa K, Tanaka K, Shirakawa M. "Resonance assignments, solution structure, and backbone dynamics of the DNA- and RPA-binding domain of human repair factor XPA." J Biochem (Tokyo). 1999; 125(3): 495-506. PubMed: 10050037
Comments:
 



Region 6
Type:Ordered
Name: 
Location:180 - 205
Length:26
Region sequence:

LYLKLQIVKRSLEVWGSQEALEEAKE

Modification type:  
PDB: 1XPA:A
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
  1. Nuclear magnetic resonance (NMR) (303 K; pH: 6.5; )
References:
  1. Ikegami T, Kuraoka I, Saijo M, Kodo N, Kyogoku Y, Morikawa K, Tanaka K, Shirakawa M. "Solution structure of the DNA- and RPA-binding domain of the human repair factor XPA." Nat Struct Biol. 1998; 5(8): 701-706. PubMed: 9699634

  2. Ikegami T, Kuraoka I, Saijo M, Kodo N, Kyogoku Y, Morikawa K, Tanaka K, Shirakawa M. "Resonance assignments, solution structure, and backbone dynamics of the DNA- and RPA-binding domain of human repair factor XPA." J Biochem (Tokyo). 1999; 125(3): 495-506. PubMed: 10050037
Comments:
 


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