Annotation for this protein is in progress - please check future releases for more complete information


DP00245: cAMP-dependent protein kinase type I-alpha regulatory subunitFASTA viewXML view

General information
DisProt:DP00245
Name:cAMP-dependent protein kinase type I-alpha regulatory subunit
Synonym(s):KAP0_BOVIN
PKA Regulatory Subunit
PRKAR1A
First appeared in release:Release 3.0 (02/17/2006)
UniProt:P00514
UniGene:Bt.10903
SwissProt: KAP0_BOVIN
TrEMBL:  
NCBI (GI): 145559486
Source organism:Bos taurus (Bovine)
Sequence length:379
Percent disordered:6%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
ASGTTASEEE RSLRECELYV QKHNIQALLK DSIVQLCTAR PERPMAFLRE YFEKLEKEEA - 60
KQIQNLQKAG SRADSREDEI SPPPPNPVVK GRRRRGAISA EVYTEEDAAS YVRKVIPKDY - 120
KTMAALAKAI EKNVLFSHLD DNERSDIFDA MFPVSFIAGE TVIQQGDEGD NFYVIDQGEM - 180
DVYVNNEWAT SVGEGGSFGE LALIYGTPRA ATVKAKTNVK LWGIDRDSYR RILMGSTLRK - 240
RKMYEEFLSK VSILESLDKW ERLTVADALE PVQFEDGQKI VVQGEPGDEF FIILEGSAAV - 300
LQRRSENEEF VEVGRLGPSD YFGEIALLMN RPRAATVVAR GPLKCVKLDR PRFERVLGPC - 360
SDILKRNIQQ YNSFVSLSV

Region 1: 91-112

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:91 - 112
Length:22
Region sequence:

GRRRRGAISAEVYTEEDAASYV

Modification type: Complex
PDB:  
Structural/functional type: Function arises via a disorder to order transition
Functional classes:  
Functional subclasses:  
Detection methods:
  1. X-ray crystallography
References:
  1. Kim C, Xuong NH, Taylor SS. "Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA." Science. 2005; 307(5710): 690-6. PubMed: 15692043

  2. Titani K, Sasagawa T, Ericsson LH, Kumar S, Smith SB, Krebs EG, Walsh KA. "Amino acid sequence of the regulatory subunit of bovine type I adenosine cyclic 3',5'-phosphate dependent protein kinase." Biochemistry. 1984; 23(18): 4193-9. PubMed: 6487597
Comments:
 


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