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DP00254: Protein tyrosine phosphatase type IVA 3 [Isoform 1]FASTA viewXML view

General information
DisProt:DP00254
Name:Protein tyrosine phosphatase type IVA 3 [Isoform 1]
Synonym(s):TP4A3_HUMAN
EC=3.1.3.48
Protein-tyrosine phosphatase 4a3
Protein-tyrosine phosphatase of regenerating liver 3
PRL-3
PRL-R
First appeared in release:Release 3.0 (02/17/2006)
UniProt:O75365-1
UniGene:Hs.43666
SwissProt: TP4A3_HUMAN
TrEMBL:  
NCBI (GI): 68566154
Source organism:Homo sapiens (Human)
Sequence length:173
Percent disordered:20%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MARMNRPAPV EVSYKHMRFL ITHNPTNATL STFIEDLKKY GATTVVRVCE VTYDKTPLEK - 60
DGITVVDWPF DDGAPPPGKV VEDWLSLVKA KFCEAPGSCV AVHCVAGLGR APVLVALALI - 120
ESGMKYEDAI QFIRQKRRGA INSKQLTYLE KYRPKQRLRF KDPHTHKTRC CVM

Region 1: 1-7 Region 3: 69-78 Region 2: 157-173

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:1 - 7
Length:7
Region sequence:

MARMNRP

Modification type:  
PDB:  
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
  1. Nuclear magnetic resonance (NMR) (308 K; pH: 6.8; DTT (10 to 12 mM); NaCl 100 mM; phosphate (buffer) 50 mM; protein 3 mM; sodium azide 0.1 mM)
References:
  1. Kozlov G, Cheng J, Ziomek E, Banville D, Gehring K, Ekiel I. "Structural insights into molecular function of the metastasis-associated phosphatase PRL-3." J Biol Chem. 2004; 279(12): 11882-9. PubMed: 14704153
Comments:
 



Region 2
Type:Disordered
Name: 
Location:157 - 173
Length:17
Region sequence:

RLRFKDPHTHKTRCCVM

Modification type:  
PDB:  
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
  1. Nuclear magnetic resonance (NMR) (308 K; pH: 6.8; DTT (10 to 12 mM); NaCl 100 mM; phosphate (buffer) 50 mM; protein 3 mM; sodium azide 0.1 mM)
References:
  1. Kozlov G, Cheng J, Ziomek E, Banville D, Gehring K, Ekiel I. "Structural insights into molecular function of the metastasis-associated phosphatase PRL-3." J Biol Chem. 2004; 279(12): 11882-9. PubMed: 14704153
Comments:
 



Region 3
Type:Disordered
Name:acid loop
Location:69 - 78
Length:10
Region sequence:

PFDDGAPPPG

Modification type:  
PDB:  
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
  1. Nuclear magnetic resonance (NMR) (308 K; pH: 6.8; DTT (10 to 12 mM); NaCl 100 mM; phosphate (buffer) 50 mM; protein 3 mM; sodium azide 0.1 mM)
References:
  1. Kozlov G, Cheng J, Ziomek E, Banville D, Gehring K, Ekiel I. "Structural insights into molecular function of the metastasis-associated phosphatase PRL-3." J Biol Chem. 2004; 279(12): 11882-9. PubMed: 14704153
Comments:
 


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