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DP00255: Protein tyrosine phosphatase type IVA 1 [Isoform 1]FASTA viewXML view

General information
DisProt:DP00255
Name:Protein tyrosine phosphatase type IVA 1 [Isoform 1]
Synonym(s):TP4A1_HUMAN
EC=3.1.3.48
Protein-tyrosine phosphatase 4a1
Protein-tyrosine phosphatase of regenerating liver 1
PRL-1
PTP(CAAXI)
First appeared in release:Release 3.0 (02/17/2006)
UniProt:Q93096
UniGene:Hs.227777
SwissProt: TP4A1_HUMAN
TrEMBL:  
NCBI (GI): 68566217
Source organism:Homo sapiens (Human)
Sequence length:173
Percent disordered:28%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MARMNRPAPV EVTYKNMRFL ITHNPTNATL NKFIEELKKY GVTTIVRVCE ATYDTTLVEK - 60
EGIHVLDWPF DDGAPPSNQI VDDWLSLVKI KFREEPGCCI AVHCVAGLGR APVLVALALI - 120
EGGMKYEDAV QFIRQKRRGA FNSKQLLYLE KYRPKMRLRF KDSNGHRNNC CIQ

Region 1: 1-6 Region 2: 25-29 Region 3: 136-173

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:1 - 6
Length:6
Region sequence:

MARMNR

Modification type:  
PDB:  
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
  1. Nuclear magnetic resonance (NMR) (310 K; D2O 5 %)
References:
  1. Laurence JS, Hallenga K, Stauffacher CV. "1H, 15N, 13C resonance assignments of the human protein tyrosine phosphatase PRL-1." J Biomol NMR. 2004; 29(3): 417-8. PubMed: 15213447
Comments:
 



Region 2
Type:Disordered
Name:P-loop
Location:25 - 29
Length:5
Region sequence:

PTNAT

Modification type:  
PDB:  
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
  1. Nuclear magnetic resonance (NMR) (310 K; D2O 5 %)
References:
  1. Laurence JS, Hallenga K, Stauffacher CV. "1H, 15N, 13C resonance assignments of the human protein tyrosine phosphatase PRL-1." J Biomol NMR. 2004; 29(3): 417-8. PubMed: 15213447
Comments:
 



Region 3
Type:Disordered
Name: 
Location:136 - 173
Length:38
Region sequence:

KRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ

Modification type:  
PDB:  
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
  1. Nuclear magnetic resonance (NMR) (310 K; D2O 5 %)
References:
  1. Laurence JS, Hallenga K, Stauffacher CV. "1H, 15N, 13C resonance assignments of the human protein tyrosine phosphatase PRL-1." J Biomol NMR. 2004; 29(3): 417-8. PubMed: 15213447
Comments:
 



References

  1. Kozlov G, Cheng J, Ziomek E, Banville D, Gehring K, Ekiel I. "Structural insights into molecular function of the metastasis-associated phosphatase PRL-3." J Biol Chem. 2004; 279(12): 11882-9. PubMed: 14704153



Comments


Additional UniGene: Hs.706850


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