Annotation for this protein is in progress - please check future releases for more complete information


DP00259: Lysozyme CFASTA viewXML view

General information
DisProt:DP00259
Name:Lysozyme C
Synonym(s):LYSC_MELGA
EC 3.2.1.17
1,4-beta-N-acetylmuramidase C
First appeared in release:Release 3.0 (02/17/2006)
UniProt:P00703
UniGene: 
SwissProt: LYSC_MELGA
TrEMBL:  
NCBI (GI): 126619
Source organism:Meleagris gallopavo (Common turkey)
Sequence length:147
Percent disordered:13%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MRSLLILVLC FLPLAALGKV YGRCELAAAM KRLGLDNYRG YSLGNWVCAA KFESNFNTHA - 60
TNRNTDGSTD YGILQINSRW WCNDGRTPGS KNLCNIPCSA LLSSDITASV NCAKKIASGG - 120
NGMNAWVAWR NRCKGTDVHA WIRGCRL

Region 1: 64-66 Region 2: 78-80 Region 3: 88-92 Region 4: 119-125 Region 5: 147-147

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:beta-hairpin
Location:64 - 66
Length:3
Region sequence:

NTD

Modification type: Fragment
PDB:  
Structural/functional type: Relationship to function unknown
Functional classes: Unknown
Functional subclasses: Unknown
Detection methods:
  1. X-ray crystallography (pH: 8; ammonium acetate (buffer) 100 mM; NaCl (9% w/v) 50 ul; protein (6 mg per ml) 50 ml)
References:
  1. Howell PL, Almo SC, Parsons MR, Hajdu J, Petsko GA. "Structure determination of turkey egg-white lysozyme using Laue diffraction data." Acta Crystallogr B. 1992; 48 ( Pt 2): 200-7. PubMed: 1515108

  2. Margiolaki I, Wright JP, Fitch AN, Fox GC, Von Dreele RB. "Synchrotron X-ray powder diffraction study of hexagonal turkey egg-white lysozyme." Acta Crystallogr D Biol Crystallogr. 2005; 61(Pt 4): 423-32. PubMed: 15805597
Comments:
 



Region 2
Type:Disordered
Name: 
Location:78 - 80
Length:3
Region sequence:

SRW

Modification type: Fragment
PDB:  
Structural/functional type: Relationship to function unknown
Functional classes: Molecular assembly
Functional subclasses: Protein-protein binding
Detection methods:
  1. X-ray crystallography (295 K; pH: 6; NaCl (0.5 M) 200 ul; protein (per ml) 100 mg)
References:
  1. Margiolaki I, Wright JP, Fitch AN, Fox GC, Von Dreele RB. "Synchrotron X-ray powder diffraction study of hexagonal turkey egg-white lysozyme." Acta Crystallogr D Biol Crystallogr. 2005; 61(Pt 4): 423-32. PubMed: 15805597
Comments:
 



Region 3
Type:Disordered
Name: 
Location:88 - 92
Length:5
Region sequence:

PGSKN

Modification type: Fragment
PDB:  
Structural/functional type: Relationship to function unknown
Functional classes: Molecular assembly
Functional subclasses: Protein-protein binding
Detection methods:
  1. X-ray crystallography (295 K; pH: 6; NaCl (0.5 M) 200 ul; protein (per ml) 100 mg)
References:
  1. Margiolaki I, Wright JP, Fitch AN, Fox GC, Von Dreele RB. "Synchrotron X-ray powder diffraction study of hexagonal turkey egg-white lysozyme." Acta Crystallogr D Biol Crystallogr. 2005; 61(Pt 4): 423-32. PubMed: 15805597
Comments:
 



Region 4
Type:Disordered
Name: 
Location:119 - 125
Length:7
Region sequence:

GGNGMNA

Modification type: Fragment
PDB:  
Structural/functional type: Relationship to function unknown
Functional classes: Molecular assembly
Functional subclasses: Protein-protein binding
Detection methods:
  1. X-ray crystallography (295 K; pH: 6; NaCl (0.5 M) 200 ul; protein (per ml) 100 mg)
References:
  1. Margiolaki I, Wright JP, Fitch AN, Fox GC, Von Dreele RB. "Synchrotron X-ray powder diffraction study of hexagonal turkey egg-white lysozyme." Acta Crystallogr D Biol Crystallogr. 2005; 61(Pt 4): 423-32. PubMed: 15805597
Comments:
 



Region 5
Type:Disordered
Name: 
Location:147 - 147
Length:1
Region sequence:

L

Modification type: Fragment
PDB: 1TEW:A
Structural/functional type: Relationship to function unknown
Functional classes: Unknown
Functional subclasses: Unknown
Detection methods:
  1. X-ray crystallography (295 K; pH: 6; NaCl (0.5 M) 200 ul; protein (per ml) 100 mg)
References:
  1. Margiolaki I, Wright JP, Fitch AN, Fox GC, Von Dreele RB. "Synchrotron X-ray powder diffraction study of hexagonal turkey egg-white lysozyme." Acta Crystallogr D Biol Crystallogr. 2005; 61(Pt 4): 423-32. PubMed: 15805597
Comments:
 



References

  1. LaRue JN, Speck JC Jr. "Turkey egg white lysozyme. Preparation of the crystalline enzyme and investigation of the amino acid sequence." J Biol Chem. 1970; 245(8): 1985-91. PubMed: 5440837



Comments


The sequence for this protein was obtained from LaRue et al. SwissProt has a Asn instead of a Asp at postion 103 of the fragment.


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