Annotation for this protein is in progress - please check future releases for more complete information


DP00265: Major prion proteinFASTA viewXML view

General information
DisProt:DP00265
Name:Major prion protein
Synonym(s):PRIO_MOUSE
PrP
PrP27-30
PrP33-35C
First appeared in release:Release 3.0 (02/17/2006)
UniProt:P04925
UniGene:Mm.648
SwissProt: PRIO_MOUSE
TrEMBL:  
NCBI (GI): 130914
Source organism:Mus musculus (Mouse)
Sequence length:254
Percent disordered:39%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MANLGYWLLA LFVTMWTDVG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP PQGGTWGQPH - 60
GGGWGQPHGG SWGQPHGGSW GQPHGGGWGQ GGGTHNQWNK PSKPKTNLKH VAGAAAAGAV - 120
VGGLGGYMLG SAMSRPMIHF GNDWEDRYYR ENMYRYPNQV YYRPVDQYSN QNNFVHDCVN - 180
ITIKQHTVTT TTKGENFTET DVKMMERVVE QMCVTQYQKE SQAYYDGRRS SSTVLFSSPP - 240
VILLISFLIF LIVG

Region 1: 23-120

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:23 - 120
Length:98
Region sequence:

KKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGTWGQPHGGGWGQPHGGSWGQPHGGSWGQ
PHGGGWGQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAV

Modification type: Fragment
PDB:  
Structural/functional type:  
Functional classes:  
Functional subclasses:  
Detection methods:
  1. Nuclear magnetic resonance (NMR) (293 K; pH: 4.5; COMPLETE (protease inhibitor cocktail); D2O 10 %; EDTA 0.01 mM; H2O 90 %; Pepstatin 0.1 uM; PMSF 0.01 mM; protein 0.8 mM)
References:
  1. Riek R, Hornemann S, Wider G, Glockshuber R, Wuthrich K. "NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231)." FEBS Lett. 1997; 413(2): 282-8. PubMed: 9280298
Comments:
 



References

  1. Lopez Garcia F, Zahn R, Riek R, Wuthrich K. "NMR structure of the bovine prion protein." Proc Natl Acad Sci U S A. 2000; 97(15): 8334-9. PubMed: 10899999


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