Annotation for this protein is in progress - please check future releases for more complete information


DP00272: Mu-type opioid receptor [Isoform 1]FASTA viewXML view

General information
DisProt:DP00272
Name:Mu-type opioid receptor [Isoform 1]
Synonym(s):OPRM_HUMAN
Mu opioid receptor
MOP
hMOP
Mu opiate receptor
MOR-1
First appeared in release:Release 3.0 (02/17/2006)
UniProt:P35372-1
UniGene:Hs.2353
SwissProt: OPRM_HUMAN
TrEMBL:  
NCBI (GI): 2851402
Source organism:Homo sapiens (Human)
Sequence length:400
Percent disordered:4%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MDSSAAPTNA SNCTDALAYS SCSPAPSPGS WVNLSHLDGN LSDPCGPNRT DLGGRDSLCP - 60
PTGSPSMITA ITIMALYSIV CVVGLFGNFL VMYVIVRYTK MKTATNIYIF NLALADALAT - 120
STLPFQSVNY LMGTWPFGTI LCKIVISIDY YNMFTSIFTL CTMSVDRYIA VCHPVKALDF - 180
RTPRNAKIIN VCNWILSSAI GLPVMFMATT KYRQGSIDCT LTFSHPTWYW ENLLKICVFI - 240
FAFIMPVLII TVCYGLMILR LKSVRMLSGS KEKDRNLRRI TRMVLVVVAV FIVCWTPIHI - 300
YVIIKALVTI PETTFQTVSW HFCIALGYTN SCLNPVLYAF LDENFKRCFR EFCIPTSSNI - 360
EQQNSTRIRQ NTRDHPSTAN TVDRTNHQLE NLEAETAPLP

Region 1: 128-143

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name: 
Location:128 - 143
Length:16
Region sequence:

VNYLMGTWPFGTILCK

Modification type: Fragment
Mutant
PDB:  
Structural/functional type:  
Functional classes: Molecular recognition effectors
Functional subclasses:  
Detection methods:
  1. Circular dichroism (CD) spectroscopy, near-UV (pH: 7; NaCl (buffer) 50 mM; protein 15 uM; Tris-HCl (buffer) 10 mM)
References:
  1. Kerman A, Ananthanarayanan VS. "Expression and spectroscopic characterization of a large fragment of the mu-opioid receptor." Biochim Biophys Acta. 2005; 1747(1): 133-40. PubMed: 15680247
Comments:
The fragment used for structure determination contained residues 97-176 of the human µR.

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