Annotation for this protein is in progress - please check future releases for more complete information


DP00273: Guanine nucleotide-binding protein G(t) subunit alpha-1FASTA viewXML view

General information
DisProt:DP00273
Name:Guanine nucleotide-binding protein G(t) subunit alpha-1
Synonym(s):GNAT1_BOVIN
Transducin alpha-1 chain
First appeared in release:Release 3.0 (02/17/2006)
UniProt:P04695
UniGene:Bt.4774
SwissProt: GNAT1_BOVIN
TrEMBL:  
NCBI (GI): 121031
Source organism:Bos taurus (Bovine)
Sequence length:350
Percent disordered:3%
Homologues: 


Native sequence

        10         20         30         40         50         60
         |          |          |          |          |          |
MGAGASAEEK HSRELEKKLK EDAEKDARTV KLLLLGAGES GKSTIVKQMK IIHQDGYSLE - 60
ECLEFIAIIY GNTLQSILAI VRAMTTLNIQ YGDSARQDDA RKLMHMADTI EEGTMPKEMS - 120
DIIQRLWKDS GIQACFDRAS EYQLNDSAGY YLSDLERLVT PGYVPTEQDV LRSRVKTTGI - 180
IETQFSFKDL NFRMFDVGGQ RSERKKWIHC FEGVTCIIFI AALSAYDMVL VEDDEVNRMH - 240
ESLHLFNSIC NHRYFATTSI VLFLNKKDVF SEKIKKAHLS ICFPDYNGPN TYEDAGNYIK - 300
VQFLELNMRR DVKEIYSHMT CATDTQNVKF VFDAVTDIII KENLKDCGLF

Region 1: 340-350

Map of ordered and disordered regions







Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.


Region 1
Type:Disordered
Name:Gt alpha
Location:340 - 350
Length:11
Region sequence:

IKENLKDCGLF

Modification type:  
PDB:  
Structural/functional type: Function arises via an order to disorder transition
Functional classes:  
Functional subclasses:  
Detection methods:
  1. Nuclear magnetic resonance (NMR) (274 K; 2H2O 10 %; DTT 1 mM; EDTA 0.1 mM; KCl 100 mM; sodium phosphate (pH 7.5) 20 mM)
References:
  1. Kisselev OG, Kao J, Ponder JW, Fann YC, Gautam N, Marshall GR. "Light-activated rhodopsin induces structural binding motif in G protein alpha subunit." Proc Natl Acad Sci U S A. 1998; 95(8): 4270-5. PubMed: 9539726
Comments:
 



References

  1. Yatsunami K, Khorana HG. "GTPase of bovine rod outer segments: the amino acid sequence of the alpha subunit as derived from the cDNA sequence." Proc Natl Acad Sci U S A. 1985; 82(13): 4316-20. PubMed: 2989813


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