Disprot - Database of Protein Disorder

Annotation for this protein is in progress - please check future releases for more complete information

DP00277: Cytochrome c oxidase copper chaperone

General information
DisProt:	DP00277
Name:	Cytochrome c oxidase copper chaperone
Synonym(s):	COX17_YEAST COX copper chaperone Cox17
First appeared in release:	Release 3.0 (02/17/2006)
UniProt:	Q12287
UniGene:
SwissProt:	COX17_YEAST
TrEMBL:
NCBI (GI):	2493874
Source organism:	Saccharomyces cerevisiae (Baker's yeast)
Sequence length:	69
Percent disordered:	46%
Homologues:

Native sequence

10 20 30 40 50 60
| | | | | |
MTETDKKQEQ ENHAECEDKP KPCCVCKPEK EERDTCILFN GQDSEKCKEF IEKYKECMKG - 60
YGFEVPSAN

Map of ordered and disordered regions
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.

Region 1
Type:	Disordered
Name:
Location:	1 - 26
Length:	26
Region sequence:	MTETDKKQEQENHAECEDKPKPCCVC
Modification type:
PDB:
Structural/functional type:	Function arises from the disordered state
Functional classes:
Functional subclasses:	Metal binding Protein-protein binding
Detection methods: Nuclear magnetic resonance (NMR) (298 K; pH: 6; protein 1 mM; potassium phosphate 20 mM; TCEP 1 mM; D2O (v/v) 7 %)
References: Abajian C, Yatsunyk LA, Ramirez BE, Rosenzweig AC. "Yeast cox17 solution structure and Copper(I) binding." J Biol Chem. 2004; 279(51): 53584-92. PubMed: 15465825
Comments: This is the Cox17 protein in the apo form

Region 2
Type:	Disordered
Name:
Location:	1 - 22
Length:	22
Region sequence:	MTETDKKQEQENHAECEDKPKP
Modification type:	Complex
PDB:
Structural/functional type:	Function arises from the disordered state
Functional classes:
Functional subclasses:	Metal binding Protein-protein binding
Detection methods: Nuclear magnetic resonance (NMR) (298 K; pH: 6; CuCl (anaerobic solution) 6.1 mM; HCl (anaerobic solution) 10 mM; NaCl 100 mM; potassium phosphate 100 mM; protein 1 mM; sodium chloride (anaerobic solution) 1 M)
References: Abajian C, Yatsunyk LA, Ramirez BE, Rosenzweig AC. "Yeast cox17 solution structure and Copper(I) binding." J Biol Chem. 2004; 279(51): 53584-92. PubMed: 15465825
Comments: This is the Cox17 protein in complex with copper.

Region 3
Type:	Disordered
Name:
Location:	64 - 69
Length:	6
Region sequence:	EVPSAN
Modification type:
PDB:
Structural/functional type:	Function arises from the disordered state
Functional classes:
Functional subclasses:	Metal binding Protein-protein binding
Detection methods: Nuclear magnetic resonance (NMR) (298 K; pH: 6; D2O (v/v) 7 %; potassium phosphate 20 mM; protein 1 mM; TCEP 1 mM)
References: Abajian C, Yatsunyk LA, Ramirez BE, Rosenzweig AC. "Yeast cox17 solution structure and Copper(I) binding." J Biol Chem. 2004; 279(51): 53584-92. PubMed: 15465825
Comments: This is the Cox17 protein is its apo form.

Region 4
Type:	Disordered
Name:
Location:	64 - 69
Length:	6
Region sequence:	EVPSAN
Modification type:	Complex
PDB:
Structural/functional type:	Function arises from the disordered state
Functional classes:
Functional subclasses:	Metal binding Protein-protein binding
Detection methods: Nuclear magnetic resonance (NMR) (298 K; pH: 6; CuCl (anaerobic solution) 6.1 mM; HCl (anaerobic solution) 10 mM; NaCl 100 mM; potassium phosphate 100 mM; protein 1 mM; sodium chloride (anaerobic solution) 1 M)
References: Abajian C, Yatsunyk LA, Ramirez BE, Rosenzweig AC. "Yeast cox17 solution structure and Copper(I) binding." J Biol Chem. 2004; 279(51): 53584-92. PubMed: 15465825
Comments: This is the Cox17 protein in complex with copper.

References
Glerum DM, Shtanko A, Tzagoloff A. "Characterization of COX17, a yeast gene involved in copper metabolism and assembly of cytochrome oxidase." J Biol Chem. 1996; 271(24): 14504-9. PubMed: 8662933