Disprot - Database of Protein Disorder

Annotation for this protein is in progress - please check future releases for more complete information

DP00288: Prevent host death protein

General information
DisProt:	DP00288
Name:	Prevent host death protein
Synonym(s):	PHD_BPP1 Phd
First appeared in release:	Release 3.0 (02/17/2006)
UniProt:	Q06253
UniGene:
SwissProt:	PHD_BPP1
TrEMBL:
NCBI (GI):	730320
Source organism:	Enterobacteria phage P1 (Bacteriophage P1)
Sequence length:	73
Percent disordered:	100%
Homologues:

Native sequence

10 20 30 40 50 60
| | | | | |
MQSINFRTAR GNLSEVLNNV EAGEEVEITR RGREPAVIVS KATFEAYKKA ALDAEFASLF - 60
DTLDSTNKEL VNR

Map of ordered and disordered regions
Note: 'Mouse' over a region to see the start and stop residues. Click on a region to see detailed information.

Region 1
Type:	Disordered
Name:
Location:	1 - 73
Length:	73
Region sequence:	MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLF DTLDSTNKELVNR
Modification type:	Engineered Monomeric
PDB:
Structural/functional type:	Function arises via a disorder to order transition
Functional classes:	Molecular assembly
Functional subclasses:	Protein-DNA binding
Detection methods: Circular dichroism (CD) spectroscopy, near-UV (310 K; EDTA (buffer) 0.1 mM; NaCl (buffer) 100 mM; Tris-HCl (buffer (pH 7.4) ) 50 mM)
References: Gazit E, Sauer RT. "Stability and DNA binding of the phd protein of the phage P1 plasmid addiction system." J Biol Chem. 1999; 274(5): 2652-7. PubMed: 9915794
Comments:

References
Lehnherr H, Maguin E, Jafri S, Yarmolinsky MB. "Plasmid addiction genes of bacteriophage P1: doc, which causes cell death on curing of prophage, and phd, which prevents host death when prophage is retained." J Mol Biol. 1993; 233(3): 414-28. PubMed: 8411153